Results 41 to 50 of about 17,470 (244)

Combined Pulmonary Fibrosis and Emphysema Syndrome: A New Phenotype within the Spectrum of Smoking-Related Interstitial Lung Disease

Pulmonary Medicine, 2012
Combined pulmonary fibrosis and emphysema (CPFE) is a recently defined syndrome, in which centrilobular and/or paraseptal emphysemas in upper lung zones coexist with pulmonary fibrosis in lower lobes in individuals.
Karina Portillo, Josep Morera
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Can the single-breath alveolar volume be adjusted to estimate true total lung capacity?

European Clinical Respiratory Journal
Background Total lung capacity (TLC) measured with single-breath gas diffusion (TLCsb) is systematically lower than TLC measured with whole-body plethysmography (TLCwbp) especially in patients with obstructive defects.
Simon Kristoffer Høgh Rasmusen, Jann Mortensen   +1 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Quantifying ventilation by X-ray velocimetry in healthy adults

Respiratory Research, 2023
Rationale X-ray velocimetry (XV) has been utilized in preclinical models to assess lung motion and regional ventilation, though no studies have compared XV-derived physiologic parameters to measures derived through conventional means.
Trishul Siddharthan, Kyle Grealis, Jason P. Kirkness, Tamás Ötvös, Darko Stefanovski, Alex Tombleson, Molly Dalzell, Ernesto Gonzalez, Kinjal Bhatt Nakrani, David Wenger, Michael G. Lester, Bradley W. Richmond, Andreas Fouras, Naresh M. Punjabi   +13 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Relationship between linear and nonlinear dynamics of heart rate and impairment of lung function in COPD patients

International Journal of COPD, 2015
Adriana Mazzuco,1 Wladimir Musetti Medeiros,2 Milena Pelosi Rizk Sperling,1 Aline Soares de Souza,2 Maria Clara Noman Alencar,2 Flávio Ferlin Arbex,2 José Alberto Neder,2,3 Ross Arena,4 Audrey Borghi-Silva1 1Cardiopulmonary Physiotherapy ...
Mazzuco A, Medeiros WM, Sperling MP, Souza AS, Alencar MC, Arbex FF, Neder JA, Arena R, Borghi-Silva A   +8 more
doaj  

Retinoid treatment of Emphysema in Patients on the Alpha-1 International Registry. The REPAIR study: study design, methodology and quality control of study assessments

Therapeutic Advances in Respiratory Disease, 2010
Emphysema is characterized by the destruction of alveolar wall and enlargement of alveolar airspaces, resulting in a reduction of the total lung gas exchange area, loss of lung elastic recoil and hyperinflation.
Jan Stolk, Brendan G. Cooper, Berend Stoel, Alexis Rames, Olga Rutman, Sherif Soliman, Robert Stockley   +6 more
doaj   +1 more source

Normal lung sparing Tomotherapy technique in stage III lung cancer

Radiation Oncology, 2017
Purpose Radiation pneumonitis (RP) has been a challenging obstacle in treating stage III lung cancer patients. Beam angle optimization (BAO) technique for Tomotherapy was developed to reduce the normal lung dose for stage III non-small cell lung cancer ...
Chae-Seon Hong, Sang Gyu Ju, Yong Chan Ahn, Gyu Sang Yoo, Jae Myoung Noh, Dongryul Oh, Kwangzoo Chung, Hongryull Pyo, Kwanghyun Jo   +8 more
doaj   +1 more source

Ventilatory constraint is more severe in walking than cycling in patients with COPD

Current Research in Physiology, 2021
Due to its effectivity in assessing functional capacity and adding prognostic information to the staging of chronic obstructive pulmonary disease (COPD) patients, the 6-min walk test (6MWT) is extensively used in clinical evaluation.
Jan Chlumský, Ondřej Zindr
doaj   +1 more source