Results 41 to 50 of about 16,957 (295)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Non-covalent binding analysis of sulfamethoxazole to human serum albumin: Fluorescence spectroscopy, UV–vis, FT-IR, voltammetric and molecular modeling

Journal of Pharmaceutical Analysis, 2015
This study was designed to examine the interaction of sulfamethoxazole (SMZ) with human serum albumin(HSA). Spectroscopic analysis of the emission quenching at different temperatures revealed that the quenching mechanism of human serum albumin by SMZ was
Praveen N. Naik, Sharanappa T. Nandibewoor, Shivamurthi A. Chimatadar   +2 more
doaj   +1 more source

Effect of Quenching Media and Tempering Temperature on Fatigue Property and Fatigue Life Estimation Based on RBF Neural Network of 0.44 % Carbon Steel [PDF]

Mechanical Sciences, 2019
In this work, the effect of the quenching media (brine, water, and two types of naphthenic mineral oils) and the tempering temperature (200, 400, 600 ∘C) on the static mechanical properties and the fatigue life has been investigated using 300 ...
S. Guo, C. Li, J. Shi, F. Luan, X. Song
doaj   +1 more source

Study on the Interaction Mechanism between Galactomannan and Human Serum Albumin by Spectroscopy and Molecular Docking

Shipin gongye ke-ji, 2022
Objective: To study the effect of galactomannan on the spectral characteristics of human serum albumin (HSA) and the mechanism of their interaction. Methods: Multispectroscopic analyses were used to determine the quenching method, number of binding sites,
Jingrui WANG, Jiamin PENG, Cheng DAI, Yan LI, Xin’an XIE   +4 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Investigation of the interaction between two phenylethanoid glycosides and bovine serum albumin by spectroscopic methods

Journal of Pharmaceutical Analysis, 2013
Two phenylethanoid glycosides, acteoside and forsythoside B, were first isolated from the traditional Chinese herb Callicarpa peii H.T. Chang. The interaction between the two phenylethanoid glycosides and bovine serum albumin (BSA) was investigated by ...
Ai-Zhi Wu, Chao-Zhan Lin, Ya-Jing Zhai, Jia-Lin Zhuo, Chen-Chen Zhu   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

N-S-co-Doped Carbon Dot Blue Fluorescence Preparation and Baicalein Detection

Inorganics
Carbon dots (CDs) have emerged as significant fluorescent nanomaterials due to their bright, stable fluorescence, good biocompatibility, facile synthesis, etc.
Yujia Cheng, Yan Huang, Guang Yu
doaj   +1 more source

Carbon Dot‐Based Biosensors

Advanced NanoBiomed Research, 2021
0D fluorescent carbon dots (CDs), consisting of sp2/sp3 carbon skeletons with functional groups, have the advantages of good chemical stability, high biocompatibility, excellent dispersibility in water, and low photobleaching, as well as low toxicity and
Wei Jiang, Yuan Zhao, Xuecheng Zhu, Huilin Liu, Baoguo Sun   +4 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source