Results 61 to 70 of about 129,958 (357)

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Effect of ultrasonic rolling on the surface integrity and corrosion properties of GCr15 steel before and after quenching

open access: yesMaterials Research Express, 2022
Two new surface strengthening processes,Ultrasonic rolling treatment before and after quenching were investigated on GCr15 steel. The surface integrity and corrosion were tested and ABAQUS simulation was conducted for the two processes.
Yongchen Wang   +3 more
doaj   +1 more source

In vivo evidence for glycyl radical insertion into a catalytically inactive variant of pyruvate formate‐lyase

open access: yesFEBS Letters, EarlyView.
Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel   +2 more
wiley   +1 more source

Holographic study on the jet quenching parameter in anisotropic systems [PDF]

open access: yes, 2016
We first calculate the jet quenching parameter of an anisotropic plasma with a U(1) chemical potential via the AdS/CFT duality. The effects of charge, anisotropy parameter and quark motion direction on the jet quenching parameter are investigated.
Wang, Luying, Wu, Shang-Yu
core   +2 more sources

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

open access: yesMolecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren   +4 more
wiley   +1 more source

Momentum broadening of partons on the light cone from the lattice [PDF]

open access: yes, 2013
The jet quenching parameter describes the momentum broadening of a high-energy parton moving through the quark-gluon plasma. Following an approach originally proposed by Caron-Huot, we discuss how one can extract information on the collision kernel ...
Panero, Marco   +2 more
core   +2 more sources

Landscape of BRAF transcript variants in human cancer

open access: yesMolecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda   +5 more
wiley   +1 more source

Interactions of Amino Group Functionalized Tetraphenylvinyl and DNA: A Label-Free “On-Off-On” Fluorescent Aptamer Sensor toward Ampicillin

open access: yesBiosensors, 2023
As a type of aggregation-induced emission (AIE) fluorescent probe, tetraphenylvinyl (TPE) or its derivatives are widely used in chemical imaging, biosensing and medical diagnosis.
Weifu Geng   +6 more
doaj   +1 more source

Interaction quenches in nonzero temperature fermionic condensates [PDF]

open access: yesarXiv, 2023
We revisit the study of amplitude oscillations in a pair condensate of fermions after an interaction quench, and generalize it to nonzero temperature. For small variations of the order parameter, we show that the energy transfer during the quench determines both the asymptotic pseudo-equilibrated value of the order parameter and the magnitude of the ...
arxiv  

Zero-Temperature Coarsening in the 2d Potts Model [PDF]

open access: yesJ. Stat. Mech. P06018 (2013), 2013
We study the fate of the 2d kinetic q-state Potts model after a sudden quench to zero temperature. Both ground states and complicated static states are reached with non-zero probabilities. These outcomes resemble those found in the quench of the 2d Ising model; however, the variety of static states in the q-state Potts model (with q>=3) is much richer ...
arxiv   +1 more source

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