Results 41 to 50 of about 183,815 (267)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Assessment of Propulsion Patterns for Hybrid Wing Configuration Aircraft with Embedded Propellers

Aerospace
This study employs computational fluid dynamics (CFD) to investigate the aerodynamic performance and static stability of hybrid wing aircraft, considering the interference of counter-rotating embedded propellers. Extensive numerical verification has been
Xiaolu Wang, Changning Chen, Zhihao Jiao, Jiahao Li, Ke Zhao   +4 more
doaj   +1 more source

75-mm Wingspan Fixed-Wing Nano Air Vehicle With a Novel Aircraft Configuration

IEEE Access, 2018
The development of a fixed-wing nano air vehicle that fits inside a cube of 75 mm is described in this paper. A novel aircraft configuration that satisfies the static and dynamic stability and the mission performance requirements is developed.
Jinraj V. Pushpangathan, Harikumar Kandath, M. Seetharama Bhat   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

System static voltage stability analysis considering load characteristics of electrolytic aluminum

Energy Reports, 2022
The load characteristics have a significant impact on the static voltage stability analysis of the power grid. Wenshan power grid has a large amount of relatively centralized electrolytic aluminum load, accounting for 65% of the total local load.
Mingqiang Zhang, Siyang Liao, Jian Xu, Lingfang Li, Yixuan Chen, Xinchun Zhu   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Investigation of propeller slipstream effects on lateral and directional static stability of transport aircraft

Engineering Applications of Computational Fluid Mechanics, 2022
The aerodynamic characteristics of turboprop aircraft are greatly affected by the running propellers. In this paper, propeller slipstream effects on the static lateral-directional stability characteristics of a typical twin-engine turboprop aircraft with
Shuai Zhao, Jie Li, Youxu Jiang, Ruizhan Qian, Ruifei Xu   +4 more
doaj   +1 more source