Results 41 to 50 of about 57,852 (261)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

[18F]Fluorodeprenyl‐D2 PET as a Tool to Monitor Disease Activity in GAD65‐Ab Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate [18F]fluorodeprenyl‐D2 ([18F]F‐DED) positron‐emission tomography (PET) imaging as a biomarker of disease activity in autoimmune encephalitis (AIE) associated with glutamic acid decarboxylase 65 (GAD65) antibodies. Methods [18F]F‐DED PET was performed in 25 GAD65‐AIE patients and 8 controls using dynamic (0–60 min) and ...
Julia S. Dorneich, Jonathan A. Gernert, Hanna Zimmermann, Lisa Tagnin, Marianthi Zeinaki, Laura Sanzo, Letizia Vogler, Elisabeth Kaufmann, Justina Dargvainiene, Frank Leypoldt, Gérard N. Bischof, Robert Perneczky, Boris‐Stephan Rauchmann, Simon Lindner, Günter U. Höglinger, Rudolf A. Werner, Martin Kerschensteiner, Tania Kümpfel, Matthias Brendel, Franziska S. Thaler   +19 more
wiley   +1 more source

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

STUDY ON MESH STIFFNESS CALCULATION AND LOAD DISTRIBUTION AMONG TEETH OF HELICAL GEAR PAIR AND UNDER BROKEN TOOTH FAULT (MT)

Jixie qiangdu, 2023
The mesh stiffness calculation and load distribution among teeth of helical gear are the basis of its dynamics analysis and strength calculation. Aiming at the accuracy of approximate replacement method of mesh stiffness of helical gear, the quasi-static
WANG ZhengBing, SHI LuBing, CHEN Chao, YAN ShiDang, LIU ZhongMing   +4 more
doaj  

Does Long‐Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?

Arthritis Care &Research, EarlyView.
Objective We examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group. Methods This study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a ...
Stephen P. Messier, Matthew N. Vigliotti, Paige E. Rice, Brian Pietrosimone, Shannon L. Mihalko, Edward H. Ip, Richard F. Loeser, David J. Hunter, Ali Guermazi, Ryan Hill, Santiago Saldana, Kim L. Bennell, Paul DeVita   +12 more
wiley   +1 more source

Moderators of the Effects of Exercise and Manual Therapy for People With Knee and Hip Osteoarthritis: A Secondary Analysis of a Randomized Clinical Trial

Arthritis Care &Research, EarlyView.
Objective This study aimed to investigate potential moderators influencing the effects of manual therapy and exercise therapy on pain and functional outcomes in individuals with knee and/or hip osteoarthritis, using data from the MOA trial. This is a secondary analysis of data from the MOA trial that compares the clinical effectiveness of manual ...
Daniel Cury Ribeiro, Sarah E. Lamb, J. Haxby Abbott   +2 more
wiley   +1 more source

Structural Design and Static Stiffness Optimization of Magnetorheological Suspension for Automotive Engine

Applied Sciences
In light of the limitation that passive suspension can only provide vibration isolation within a specific range, a magnetorheological suspension in extrusion mode was developed.
Zhi Rao, Lingfeng Tang, Yifang Shi
doaj   +1 more source

STUDY ON THE STATIC TORSION STIFFNESS OF RUBBER SPRING BY EXPERIMENT AND SIMULATION (MT)

Jixie qiangdu, 2023
The effects of structural parameters, material parameters and pre-compression of rubber on the static torsion stiffness of rubber spring were studied by means of experimental research and simulated analysis.
DUAN Yu, TAO YouRui, PEI JiaXing, ZHANG Yu   +3 more
doaj  

Formal and Informal Social Care in People With Rheumatic and Musculoskeletal Diseases: A Cross‐Sectional Multicenter Survey

Arthritis Care &Research, EarlyView.
Objective Rheumatic and musculoskeletal diseases (RMDs) are leading causes of physical disability, necessitating support with activities of daily living. This study describes social care received by patients with RMDs in two disparate regions of England: Salford (urban) and Norfolk (rural).
Mehreen Somro, Karen Durrant, William G. Dixon, John McBeth, Alex MacGregor, Max Yates, Jenny H. Humphreys   +6 more
wiley   +1 more source

Static lateral stiffness of wire rope isolators [PDF]

Mechanics Based Design of Structures and Machines, 2016
This paper presents an analytical model for the static lateral stiffness of Wire Rope Isolators (WRI). The wire rope isolator, which is a passive isolation device, has been widely adopted as a shock and vibration isolation for many types of equipment and lightweight structures.
Balaji, P., Leblouba, M., Rahman, Muhammad, Ho, L.   +3 more
openaire   +2 more sources