Results 131 to 140 of about 1,115,389 (312)

Static tests of a simulated upper surface blown jet-flap configuration utilizing a full-size turbofan engine [PDF]

open access: yes
The investigation utilizing a small turbofan engine was conducted to evaluate static turning performance and pressure and temperature environment of an upper surface blown wing and flap segment.
Shivers, J. P., Smith, C. C., Jr.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

5KW pulse width modulated static inverter [PDF]

open access: yes
Design verification tests for logic and low level circuits, and preliminary single-phase breadboard of pulse width modulated static ...
Peterson, W. V., Resch, R. J.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Static and dynamic GPS receiver verification tests using software defined radio

open access: yesTeknika
Global Positioning System (GPS) is widely used in a variety of fields, including aircraft applications and rockets where speeds exceed standards. Signal simulators, which are relatively expensive, are required to test commercial GPS devices and GPS ...
Sri Kliwati   +5 more
doaj   +1 more source

Stress-corrosion behavior of aluminum-lithium alloys in aqueous environments [PDF]

open access: yes
The stress corrosion susceptibility of two powder metallurgy (P/M) alloys, Al-Li-Cu and Al-Li-Cu-Mg two mechanically attrited (M/A) alloys, Al-Li-Cu and Al-Li-Mg; and two wrought, ingot alloys, X-2020 and AA7475, are compared.
Galvin, R. P.   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

STUDY ON THE MECHANICAL PERFORMANCE AND FAILURE MODE OF CLINCHING JOINT

open access: yesJixie qiangdu, 2016
The mechanics behavior and failure characteristics of clinching joint specimens were investigated through the quasi-static tests and dynamic tests of single clinching joints under cross tension,lap shear and couch peel conditions,and also through the ...
ZHOU LuYao, LV Jie, LU ShanBin
doaj  

Acoustic tests of duct-burning turbofan jet noise simulation [PDF]

open access: yes
The results of a static acoustic and aerodynamic performance, model-scale test program on coannular unsuppressed and multielement fan suppressed nozzle configurations are summarized.
Brausch, J. F.   +5 more
core   +1 more source

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