Results 61 to 70 of about 4,175,588 (290)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Determination of static voltage stability-margin of the power system prior to voltage collapse [PDF]

, 2011
YesVoltage instability problems in power system are an important issue that should be taken into consideration during the planning and operation stages of modern power system networks.
Jalboub, Mohamed K., Ihbal, Abdel-Baset M.I., Abd-Alhameed, Raed, Rajamani, Haile S.   +3 more
core   +4 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Effect of induction motors mechanical load on its model for purpose of static voltage stability analysis [PDF]

, 2011
Load modelling is one of the major issues in voltage stability analysis. It greatly impacts the result of the study and has a significant effect on the stability regions.
Mostafa Sharifzadeh (23304724), H. Raoufi (23549695)   +1 more
core   +1 more source

Coordinated Active and Reactive Power Control of VSC-HVDC for Enhancing Static Voltage Stability in AC/DC Systems

Energies
When conducting research on the static voltage stability of AC/DC systems with voltage source converter-high voltage direct current (VSC-HVDC) transmission lines, the focus is often given to reactive power control, neglecting the potential from active ...
Jinpeng Guo, Luo Zou, Ningyu Zhang, Yuqiao Jia, Xueping Pan, Xiaorong Sun   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Comparative Study of SVC and STATCOM Reactive Power Compensation for Prosumer Microgrids With DFIG-Based Wind Farm Integration

IEEE Access, 2020
Uncertainties of renewable energy sources like wind power are one of the considerable challenges of prosumer microgrids. To meet the grid codes requirements regarding the voltage stability of wind farm integration, finding the balance between providing ...
Jun Qi, Wenbin Zhao, Xiaoyan Bian
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source