Results 211 to 220 of about 947,634 (291)

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine from Xylose in Escherichia coli

open access: yesAdvanced Science, EarlyView.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han   +5 more
wiley   +1 more source

PROTAC‑Mediated HMGCR Depletion Reprograms Lipid Metabolism in Breast Cancer to Potentiate Photoimmunotherapy via Ferroptosis

open access: yesAdvanced Science, EarlyView.
This work introduces a study that identifies HMGCR as a novel target in TNBC and develops a light‐gated PROTAC nanomedicine. Upon irradiation, this agent selectively degrades HMGCR, reprogramming lipid metabolism to induce ferroptosis and potent antitumor immunity, thereby significantly enhancing photoimmunotherapy efficacy.
Tong Su   +18 more
wiley   +1 more source

The decline of 'Deaths of Despair' in Italy: unveiling this phenomenon in a new context. [PDF]

open access: yesPopul Health Metr
Lanfiuti Baldi G   +3 more
europepmc   +1 more source

All‐Optical Control of Bidirectional Polarization Switching in Ferroelectric Heterostructures for Neuromorphic and In‐Memory Computing

open access: yesAdvanced Science, EarlyView.
We propose an optical ferroelectric field‐effect transistor, composed of a MoS2/CIPS heterostructure, demonstrates the feasibility of all‐optical nonvolatile memory, neuromorphic computing, and logic‐in‐memory operations. The device exhibits reversible light‐controlled memory states, retina‐like synaptic plasticity, and wavelength‐selective ...
Jingjie Niu   +7 more
wiley   +1 more source

Enhanced Photocatalytic CO2 Reduction Performance by External Electric Field‐Driven Charge Separation on Interdigitated Micro‐Spacing Structure

open access: yesAdvanced Science, EarlyView.
An external electric field‐enhanced photocatalytic system is developed using interdigitated electrodes with 100 µm spacing to overcome the liquid‐phase limitations of traditional PEC. The induced high‐intensity electric field effectively drives the directional migration of charge carriers under low voltage. This strategy significantly suppresses charge
Xidan Tang   +7 more
wiley   +1 more source

Tunable Plug‐and‐Play Meta‐Nanogenerator Materials for Multi‐Range Force Measurements

open access: yesAdvanced Science, EarlyView.
The multifunctional and tunable meta‐nanogenerator material system combines a mechanical metamaterial and a triboelectric nanogenerator enabling self‐powered, real‐time force sensing across application‐specific ranges. Geometrical tuning adjusts stiffness and the force sensing range, while modular integration streamlines assembly.
Roshira Premadasa   +6 more
wiley   +1 more source

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