Results 31 to 40 of about 500 (259)
International Journal of Constitutional Law, 2019 Abstract In this Foreword, we wish to insert a degree of innovation into debates about global law and the supposed demise of state-based public law. We do so by asking how considerations of space, place and density impact the conceptualization and utilization of state power in a world of growing complexity and interdependence.
Hirschl, Ran, Shachar, Ayelet
openaire +2 more sources
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Global Justice and Open Borders: An Inclusive Statist Account
PhilosophiesStandard arguments for open borders draw on cosmopolitan premises. By contrast, statism as a theory of global justice seems to be at odds with open borders.
Borja Niño Arnaiz
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Luigi Sturzo sulla “Plain fascist economics” di Herbert Hoover [PDF]
Storia e PoliticaSturzo during his exile in America intervened in the political debate dealing with various topics; diplomacy, society, problems of Catholics and also economic issues.
Vincenzo Pintaudi
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Uluslararası Ekonomi, İşletme ve Politika Dergisi, 2019 Tarımsal kalkınma, tarım alanında pazarlama imkânlarınıngeliştirilmesi, ürün kalite ve çeşitliliğinin artırılması ve en önemlisi üretimartışı sağlanarak ülke refahını yükseltmeye yönelik çalışmaları kapsayanuygulamalar bütünüdür.
Sezgin Uysal, Mehmet Ali Bacaksız
doaj +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source