Results 241 to 250 of about 2,103,887 (342)

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Full BLOOD count TRends for colorectal cAnCer deteCtion (BLOODTRACC): external validation of colorectal cancer prediction models in English primary care

Virdee PS, Birks J, Holt T, Snell KI, Abel G, Nicholson BD.   +5 more
europepmc   +1 more source

Predictive Value of Serum N-Terminal pro-B-Type Natriuretic Peptide and Troponin T for Incident Heart Failure: A Meta-Analysis of 9 International Cohorts. [PDF]

J Am Heart Assoc
Bansal N, Grams ME, Coresh J, Matsushita K, Ballew SH, Sang Y, Surapaneni A, Ärnlöv J, Bell S, Berry JD, Damman K, de Lemos JA, Dobre M, Hwang SJ, Gansevoort RT, Shlipak MG, Schneider MP, CKD Prognosis Consortium.   +17 more
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Comparative Efficacy and Toxicity of Weekly Carboplatin Versus Cisplatin in Concurrent Chemoradiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma: A Quasi-experimental Study From Bangladesh. [PDF]

Cureus
Sweet AAM, Haque ME, Mannan MA, Bhuiyan MRA, Chowdhury AP, Bayzid KMR, Sumsuzoha AZM, Arifeen MA.   +7 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Climate resilience of public health preventive and adaptive measures against diarrhea in Northern Ghana; a case study of the Tamale Metropolitan Area. [PDF]

BMC Public Health
Abdul-Ganiu Z, Shamsu-Deen Z, Yakubu A.
europepmc   +1 more source

Long-Horizon Associative Learning Explains Human Sensitivity to Statistical and Network Structures in Auditory Sequences

Lucas Benjamin, Mathias Sablé-Meyer, Ana Fló, Ghislaine Dehaene‐Lambertz, Fosca Al Roumi   +4 more
openalex   +2 more sources

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Stepwise connectivity of the entorhinal cortex along connectomic gradients in Alzheimer's disease. [PDF]

Brain Commun
Tan JXM, Kang MS, Yeh YH, Bezgin G, Lussier FZ, Hong SJ, Isen J, Rahmouni N, Vitali P, Montembeault M, Klostranec JM, Macedo AC, Chan T, McLaurin J, Swardfager W, Bernhardt BC, Stefanovic B, Soucy JP, Gauthier S, Black SE, Rosa-Neto P, Ottoy J, Goubran M.   +22 more
europepmc   +1 more source