Results 41 to 50 of about 11,468,989 (327)

Recognition of Metal Ion Ligand-Binding Residues by Adding Correlation Features and Propensity Factors

Frontiers in Genetics, 2022
The realization of many protein functions is inseparable from the interaction with ligands; in particular, the combination of protein and metal ion ligands performs an important biological function.
Shuang Xu, Shuang Xu, Xiuzhen Hu, Xiuzhen Hu, Zhenxing Feng, Zhenxing Feng, Jing Pang, Jing Pang, Kai Sun, Kai Sun, Xiaoxiao You, Xiaoxiao You, Ziyang Wang, Ziyang Wang   +13 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Federated Learning Based on Kernel Local Differential Privacy and Low Gradient Sampling

IEEE Access
Federated learning that is an approach to addressing the “data silo” problem in a collaborative fashion may face the risk of data leakage in real-world contexts.
Yi Chen, Dan Chen, Niansheng Tang
doaj   +1 more source

Inverse Optimal Adaptive H8 Consensus Control of Multi-Agent Systems on Directed Network Graphs

SICE Journal of Control, Measurement, and System Integration, 2018
Design methods of inverse optimal adaptive H8 consensus control of multi-agent systems denoted by the first-order and the second-order regression models on directed network graphs are presented in this paper.
Yoshihiko Miyasato
doaj   +1 more source

Prediction of metal ion ligand binding residues by adding disorder value and propensity factors based on deep learning algorithm

Frontiers in Genetics, 2022
Proteins need to interact with different ligands to perform their functions. Among the ligands, the metal ion is a major ligand. At present, the prediction of protein metal ion ligand binding residues is a challenge. In this study, we selected Zn2+, Cu2+,
Sixi Hao, Sixi Hao, Xiuzhen Hu, Xiuzhen Hu, Zhenxing Feng, Zhenxing Feng, Kai Sun, Kai Sun, Xiaoxiao You, Xiaoxiao You, Ziyang Wang, Ziyang Wang, Caiyun Yang, Caiyun Yang   +13 more
doaj   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Datasets on how misinformation promotes immune perception of COVID-19 pandemic in Africa

Data in Brief, 2020
The dataset investigates the magnitude of the misinformation content influencing scepticisms about the novel COVID-19 pandemic in Africa. The data is collected via an electronic questionnaire method and twenty-one Africa countries randomly participated ...
Olalekan Akintande, Olusanya Olubusoye
doaj   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Statistical and machine learning methods for spatially resolved transcriptomics data analysis [PDF]

, 2022
Zexian Zeng, Yawei Li, Yiming Li, Yuan Luo   +3 more
openalex   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source