Results 81 to 90 of about 11,222,791 (325)

An mHealth intervention: Associations between Theory of Planned Behaviour constructs for physical activity and longitudinal smoking related behavioural data.

Frontiers in Public Health, 2015
Background Physical activity behaviour is considered as a satisfactory additional aid method for quit smoking programs. Moreover, laboratory based studies provide strong evidence that physical activity acutely reduces cigarette cravings.
Mary Hassandra, Risto Heikkinen, Tarja Kettunen   +2 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

The Statistical Analysis of Behavioural Latency Measures [PDF]

, 1997
This article concerns two important problems with the statistical analysis of behavioural latency measures: they typically have severely skewed distributions, and are often censored (truncated).
Budaev, Dr. Sergey
core  

Multiscale statistical analysis of coronal solar activity

, 2016
Multi-filter images from the solar corona are used to obtain temperature maps which are analyzed using techniques based on proper orthogonal decomposition (POD) in order to extract dynamical and structural information at various scales.
del-Castillo-Negrete, Diego, Gamborino, Diana, Martinell, Julio J.   +2 more
core   +2 more sources

A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies

Scientific Reports, 2017
Single nucleotide variants (SNVs) identified in cancer genomes can be de-convolved using non-negative matrix factorization (NMF) into discrete trinucleotide-based mutational signatures indicative of specific cancer-causing processes. The stability of NMF-
Philip R. Davidson, Amy L. Sherborne, Barry Taylor, Alice O. Nakamura, Jean L. Nakamura   +4 more
doaj   +1 more source

The 2-good-neighbour diagnosability of modified bubble-sort graphs under the PMC and MM* model

Systems Science & Control Engineering, 2020
The study of interconnection networks is a hot topic for multiprocessor systems. Diagnosability plays an important role in the study of interconnection networks. A new measure for fault diagnosis of a system is proposed by Peng et al. in 2012.
Yanling Wang, Shiying Wang
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Statistical Analysis of Airport Network of China

, 2003
Through the study of airport network of China (ANC), composed of 128 airports (nodes) and 1165 flights (edges), we show the topological structure of ANC conveys two characteristics of small worlds, a short average path length (2.067) and a high degree of
A.-L. Barabási, B. Bollobás, D. ben Avraham, D. J. Watts, P. Erdös, P. Erdös, P. Erdös, R. J. Williams, S. Milgram, V. Pareto, W. Li, X. Cai   +11 more
core   +1 more source