Results 81 to 90 of about 11,761,096 (290)

Statistical Analysis of Airport Network of China

, 2003
Through the study of airport network of China (ANC), composed of 128 airports (nodes) and 1165 flights (edges), we show the topological structure of ANC conveys two characteristics of small worlds, a short average path length (2.067) and a high degree of
A.-L. Barabási, B. Bollobás, D. ben Avraham, D. J. Watts, P. Erdös, P. Erdös, P. Erdös, R. J. Williams, S. Milgram, V. Pareto, W. Li, X. Cai   +11 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies

Scientific Reports, 2017
Single nucleotide variants (SNVs) identified in cancer genomes can be de-convolved using non-negative matrix factorization (NMF) into discrete trinucleotide-based mutational signatures indicative of specific cancer-causing processes. The stability of NMF-
Philip R. Davidson, Amy L. Sherborne, Barry Taylor, Alice O. Nakamura, Jean L. Nakamura   +4 more
doaj   +1 more source

Statistical analysis of scars in stadium billiard

, 1997
In this paper, by using our improved plane wave decomposition method, we study the scars in the eigenfunctions of the stadium billiard from very low state to as high as about the one millionth state. In the systematic searching for scars of various types,
Bambi Hu, Baowen Li, Berry M, Berry M, Bohigas O, Bäcker A, Frischat S, Heller E J, Klakow D, Li B, Li B, McDonald S W, Ozorio de Almeida A M, Prosen T, Robnik M, Shnirelman A L, Sieber M, Sridhar S, Tanner G, Voros A   +19 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

GNA: new framework for statistical data analysis

, 2019
We report on the status of GNA --- a new framework for fitting large-scale physical models. GNA utilizes the data flow concept within which a model is represented by a directed acyclic graph.
Fatkina, Anna, Gonchar, Maxim, Kalitkina, Anastasia, Kolupaeva, Liudmila, Naumov, Dmitry, Selivanov, Dmitry, Treskov, Konstantin   +6 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Evolution of a geometric constant along the Ricci flow

Journal of Inequalities and Applications, 2016
In this paper, we establish the first variation formula of the lowest constant λ a b ( g ) $\lambda_{a}^{b}(g)$ along the Ricci flow and the normalized Ricci flow, such that to the following nonlinear equation there exist positive solutions: − Δ u + a u ...
Guangyue Huang, Zhi Li
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source