Results 131 to 140 of about 1,288,587 (289)
, 2008 We present a test of different error estimators for 2-point clustering statistics, appropriate for present and future large galaxy redshift surveys. Using an ensemble of very large dark matter LambdaCDM N-body simulations, we compare internal error estimators (jackknife and bootstrap) to external ones (Monte-Carlo realizations).
Norberg, Peder +3 more
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Fragmented perspective of self-organized criticality and disorder in log gravity
Journal of High Energy PhysicsWe use a statistical model to discuss nonequilibrium fragmentation phenomena taking place in the stochastic dynamics of the log sector in log gravity. From the canonical Gibbs model, a combinatorial analysis reveals an important aspect of the n-particle ...
Yannick Mvondo-She
doaj +1 more source
$\mathcal{I}_\lambda$-statistical limit points and $\mathcal{I}_\lambda$-statistical cluster points
Malaya Journal of Matematik, 2021 Prasanta Malik, Samiran Das
openaire +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A New Approach to Define the Number of Clusters for Partitional Clustering Algorithms
Transactions on Fuzzy Sets and SystemsData clustering consists of grouping similar objects according to some characteristic. In the literature, there are several clustering algorithms, among which stands out the Fuzzy C-Means (FCM), one of the most discussed algorithms, being used
Huliane Silva +4 more
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
MATERIAL SELECTION WITH A STATISTICAL METHOD [PDF]
Fiabilitate şi Durabilitate, 2019 The paper presents an overview of the methods in the materials selection, offers some statistical heuristics in the decision process and a few ideas about a statistical approach for engineering applications, with some solved numerical examples.
Adrian Stere PARIS, Constantin TÂRCOLEA
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