Results 91 to 100 of about 199,661 (312)

Computers, the Second Revolution in Statistics

Biometrics, 1966
May I first express my appreciation of the honour our new President of the Royal Society, Professor Blackett, has done Sir Ronald Fisher by consenting to take the Chair tonight. I am particularly pleased that he is presiding at this meeting as not only was he an old friend of Sir Ronald, but it was also he and the then Secretary of the Agricultural ...
openaire   +2 more sources

Statistical Interpolation of Tidal Datums and Computation of Its Associated Spatially Varying Uncertainty

Journal of Marine Science and Engineering, 2016
Tidal datums are key components in NOAA’s Vertical Datum transformation project (VDatum). In this paper, we propose a statistical interpolation method, derived from the variational principle, to calculate tidal datums by blending the modeled and the ...
Lei Shi, Edward Myers
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Combinatorial Optimization with Information Geometry: The Newton Method

Entropy, 2014
e discuss the use of the Newton method in the computation of max(p → Εp [f]), where p belongs to a statistical exponential family on a finite state space.
Luigi Malagò, Giovanni Pistone
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

conting : an R package for Bayesian analysis of complete and incomplete contingency tables [PDF]

, 2014
The aim of this paper is to demonstrate the R package conting for the Bayesian analysis of complete and incomplete contingency tables using hierarchical log-linear models.
Ruth King, Overstall, Antony, Antony M. Overstall, King, Ruth, Antony M. Overstall, Overstall, Antony M.   +5 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Automatic files in statistical systems [PDF]

, 1967
The existing statistical systems are designed for satisfying conditions which are changing rapidly today. The most marked feature of the existing systems of many countries is their extensive periodic surveys.
Nordbotten, Svein
core  

A selective review on statistical methods for massive data computation: distributed computing, subsampling, and minibatch techniques

Statistical Theory and Related Fields
This paper presents a selective review of statistical computation methods for massive data analysis. A huge amount of statistical methods for massive data computation have been rapidly developed in the past decades.
Xuetong Li, Yuan Gao, Hong Chang, Danyang Huang, Yingying Ma, Rui Pan, Haobo Qi, Feifei Wang, Shuyuan Wu, Ke Xu, Jing Zhou, Xuening Zhu, Yingqiu Zhu, Hansheng Wang   +13 more
doaj   +1 more source