Results 51 to 60 of about 976,015 (308)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Iterative Determination of Distributions by the Monte Carlo Method in Problems with an External Source

, 2013
In the Monte Carlo (MC) method statistical noise is usually present. Statistical noise may become dominant in the calculation of a distribution, usually by iteration, but is less Important in calculating integrals.
Makai, Mihály, Szatmáry, Zoltán
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

DOUBLE WEIGHTED LACUNARY ALMOST STATISTICAL CONVERGENCE OF ORDER α [PDF]

Romanian Journal of Mathematics and Computer Science, 2016
In this paper, we define and study the concept of double weighted lacunary almost statistical convergence of order α. Further, some inclusion relations have been examined.
SUKRAN KONCA, EKREM SAVAS, SELMAN EKIN
doaj  

On Modulated Lacunary Statistical Convergence of Double Sequences

Mathematics, 2023
In earlier works, F. León and coworkers discovered a remarkable structure between statistical convergence and strong Cesàro convergence, modulated by a function f (called a modulus function).
María del Pilar Romero de la Rosa
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Statistical Soft Wijsman Convergence

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
The concept of convergence is a fundamental tool for building or understanding a mathematical structure. In particular, many applied areas of mathematics require the analysis of sets or set-based approximations.
Erdal Bayram
doaj   +1 more source

ON WIJSMAN DEFERRED STATISTICAL CONVERGENCE OF DOUBLE SEQUENCES OF SETS [PDF]

, 2023
Mehmet Çağrı Yilmazer, Mikâil Et, Vinod Kumar Bhardwaj, Sandeep Gupta   +3 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Approximation via statistical $K_{a}^{2}$-convergence on two-dimensional weighted spaces [PDF]

, 2022
Sevda Yıldız
openalex   +1 more source