Results 131 to 140 of about 44,596,160 (284)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Wise Roles and Future Visionary Endeavors of Current Emperor: Advancing Dynamic Methods for Longitudinal Microbiome Meta‐Omics Data in Personalized and Precision Medicine

open access: yesAdvanced Science
Understanding the etiological complexity of diseases requires identifying biomarkers longitudinally associated with specific phenotypes. Advanced sequencing tools generate dynamic microbiome data, providing insights into microbial community functions and
Vera‐Khlara S. Oh, Robert W. Li
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Exact statistical inference for categorical data

open access: yes, 2016
Exact Statistical Inference for Categorical Data discusses the way asymptotic approaches have been often used in practice to make statistical inference. This book introduces both conditional and unconditional exact approaches for the data in 2 by 2, or 2
Shan, Guogen, Shan, Guogen,author.
core  

Advances in statistical models for data analysis

open access: yes, 2015
This edited volume focuses on recent research results in classification, multivariate statistics and machine learning and highlights advances in statistical models for data analysis.
Minerva, Tommaso   +5 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Gaussian Process Modeling Coronal X-Ray Variability of Active Galactic Nuclei

open access: yesThe Astrophysical Journal
The corona is an integral component of active galactic nuclei (AGNs) that can produce the X-ray emission. However, many of its physical properties and the mechanisms powering this emission remain a mystery.
Haiyun Zhang   +3 more
doaj   +1 more source

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