Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Introducing a New Research Design: The Multidimensional Interpretative Textual (MIT) Design. Epistemological and Methodological Foundations. [PDF]
Nurs InqFigura M, Arcadi P, Vellone E.
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Rainfall frequency and uncertainty analysis in arid regions using machine learning and statistical distribution models based on a 91-year rainfall record. [PDF]
Sci RepHagage M.
europepmc +1 more source
JADT 2010 INTERNATIONAL CONFERENCE ON STATISTICAL ANALYSIS OF TEXTUAL DATA
, 2010 JADT is open to all scholars and researchers working in the field of textual data analysis, ranging from lexicography to the analysis of political discourse, from information retrieval to marketing research, from computational linguistics to ...
BOLASCO, Sergio
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Network propagation in bipartite metabolite-reaction graphs for metabolomic data exploration. [PDF]
MetabolomicsKuligowski J +4 more
europepmc +1 more source
Identification of Statistical Energy Analysis Parameters from Measured Data
, 2003 An approach for identifying statistical energy analysis (SEA) parameters from experimental investigation is presented. Specifically, a power flow realization method (PRM) and statistical energy analysis model improvement (SMI) technique using transient ...
Gregory, Joseph William
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
A practical approach for regulatory acceptance of virtual control groups: vehicle pooling and biological relevance assessment. [PDF]
Front ToxicolKim J, Kim Y, Park D, Kim SK, Kang MG.
europepmc +1 more source