Results 161 to 170 of about 1,796,099 (244)

Clinical Epigenomics in Rare Diseases: Interpreting DNA Methylation Episignatures. [PDF]

Mol Genet Genomic Med
Goel H, Goh S, Stuart L.
europepmc   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

From Cluster to Claim: Calibrating Interpretation in Single-Cell Transcriptomics. [PDF]

Adv Genet (Hoboken)
Lin S, Yu G.
europepmc   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Beyond balance: propensity scores and causal reasoning. [PDF]

Korean J Anesthesiol
Ahn E.
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Letter to Editor: Validity and Reliability of a Laser Pointer Device to Assess Knee Proprioception in Healthy and Active Individuals. [PDF]

Physiother Res Int
Kabba D, Goyal K, Kalra R.
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Emergency Department Feasibility of the Brief Test of Adult Cognition by Telephone (BTACT) for Research in Mild Traumatic Brain Injury. [PDF]

Acad Emerg Med
Barton DJ, Rudolph CF, Kalinina EK, Reddy K, Gallo N, Morford H, Zeng X, Karikari TK, Pacella-LaBarbara ML, Callaway CW, Wagner AK.   +10 more
europepmc   +1 more source