Results 241 to 250 of about 8,971 (314)

Climate Change Impacts on Hydrology in the Upper James Watershed, Virginia

open access: yesJAWRA Journal of the American Water Resources Association, Volume 62, Issue 2, April 2026.
ABSTRACT Hydrological modeling of the Upper James Watershed (UJW), Virginia, is critical for predicting water availability, flood management, agriculture, ecosystem protection, and hydropower production under increasing climate change. The Hydrologic Engineering Center–Hydrologic Modeling System (HEC‐HMS) is applied to evaluate climate change impacts ...
Imiya Mudiyanselage Chathuranika   +1 more
wiley   +1 more source

Nintedanib Lacks Efficacy in a Spirometry‐Confirmed and Bleomycin‐Induced Mouse Model of Idiopathic Pulmonary Fibrosis

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Nintedanib, a multitargeted tyrosine kinase inhibitor, is approved for idiopathic pulmonary fibrosis (IPF) for its ability to slow lung function decline. This study systematically evaluated the effects of nintedanib across three independent treatment intervention studies in the single‐dose bleomycin (BLEO) mouse model of IPF.
Jamal Bousamaki   +12 more
wiley   +1 more source

Single‐Cell Transcriptomic Analysis of Chemotherapy‐Induced Changes in Osteosarcoma With a Pyroptosis‐Related Gene‐Based Prognostic Model

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Osteosarcoma, the most common primary malignant bone tumour, presents significant treatment challenges due to its complex tumour microenvironment and the development of chemoresistance. This study employs single‐cell transcriptomics to investigate chemotherapy‐induced changes in osteosarcoma at both the cellular and molecular levels.
Tao Jin   +5 more
wiley   +1 more source

Urban Heat Island in the Eastern Mediterranean and Middle East: Multi‐City Approach in Regional Climate Modelling

open access: yesInternational Journal of Climatology, Volume 46, Issue 4, 30 March 2026.
This study presents that the WRF model, coupled with bulk urban parameterization, effectively captures the summer urban heat island (UHI) patterns across the Eastern Mediterranean and Middle East, showing stronger night‐time surface UHIs (5°C–6°C) and daytime surface cool islands (up to 12.5°C).
Katiana Constantinidou   +4 more
wiley   +1 more source

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