Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The shaping of adolescent physical activity habitus: The role of family sports culture. [PDF]
Zheng H, Xiang Z, Yang W, Xi H.
europepmc +1 more source
STATISTICAL ANALYSIS OF MATERNAL AND FETAL RISK FACTORS ASSOCIATED WITH INTRAUTERINE FETAL DEMISE
Ruhide AZEMI NEZIRI +10 more
openalex +1 more source
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Spatial patterns and socio-environmental determinants of gonorrhea incidence in China. [PDF]
Hu K +6 more
europepmc +1 more source
Dimer Fatty Acid-Based Polyamide/Organoclays: Structural, Thermal Properties, and Statistical Analysis of Factors Affecting Polymer Chain Intercalation in Bentonite Layers [PDF]
Afonso D. Macheca +5 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Spike count analysis for multiplexing inference (SCAMPI). [PDF]
Chen Y, Groh JM, Tokdar S.
europepmc +1 more source
Statistical analysis of factors affecting monoclonal antibody production by using principal component analysis : molecular markers [PDF]
Zun Jia Gan
openalex

