Results 71 to 80 of about 6,703,122 (335)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Effectiveness of Ergonomic Chair Against Musculoskeletal Disorders in Female Batik Workers of Sragen District [PDF]

open access: yes, 2014
The majority of female batik workers uses non-ergonomic chairs (dingklik) that pose risks of musculoskeletal disorders. This study aimed to design an ergonomic chair and evaluate its effectiveness in reducing musculoskeletal disorders among the workers ...
Handayani, S. (Selfi)   +4 more
core  

Lexikos at eighteen: an analysis [PDF]

open access: yes, 2009
At eighteen, Lexikos became a major player in the field of linguistics, by being awarded an Impact Factor. This article presents a double analysis of the foundation that led to this success. On the one hand a thorough statistical study is undertaken with
de Schryver, Gilles-Maurice
core   +2 more sources

A study of the relationship between Bispectral index and age-adjusted minimum alveolar concentration during the maintenance phase of general anesthesia in elective surgery

open access: yesJournal of Anaesthesiology Clinical Pharmacology
Background and Aims: Bispectral index (BIS) and minimum alveolar concentration (MAC) are commonly used to monitor the depth of anesthesia. The objective was to study the correlation between BIS and age-adjusted minimum alveolar concentration (aaMAC ...
Nishant Kumar, Gunjan Bansal, Aruna Jain
doaj   +1 more source

The postgraduate medical educational climate assessed by the Danish Residency Educational Climate Test (DK-RECT): a validation and cross-sectional observational study

open access: yesBMC Medical Education, 2023
Background A good educational climate is essential for delivering high-quality training for medical trainees, professional development, and patient care. The aim of this study was to (1) validate the Dutch Residency Educational Climate Test (D-RECT) in a
Rikke Borre Jacobsen   +13 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Validation of the Registered Nurse Assessment of Readiness for Hospital Discharge Scale [PDF]

open access: yes, 2018
Background Statistical models for predicting readmissions have been published for high-risk patient populations but typically focus on patient characteristics; nurse judgment is rarely considered in a formalized way to supplement prediction models ...
Bobay, Kathleen L.   +3 more
core   +3 more sources

On applications of the factor analysis in the agricultural research

open access: yesAgricultural Economics (AGRICECON), 2007
The authors give a brief overview of the outcomes of an application of the factor analysis and present results of two applications within the agricultural research.
V. Brabenec, H. Nešetřilová
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

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