Results 81 to 90 of about 11,717,635 (369)

Effectiveness of Ergonomic Chair Against Musculoskeletal Disorders in Female Batik Workers of Sragen District [PDF]

open access: yes, 2014
The majority of female batik workers uses non-ergonomic chairs (dingklik) that pose risks of musculoskeletal disorders. This study aimed to design an ergonomic chair and evaluate its effectiveness in reducing musculoskeletal disorders among the workers ...
Handayani, S. (Selfi)   +4 more
core  

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

open access: yesFEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

A study of the relationship between Bispectral index and age-adjusted minimum alveolar concentration during the maintenance phase of general anesthesia in elective surgery

open access: yesJournal of Anaesthesiology Clinical Pharmacology
Background and Aims: Bispectral index (BIS) and minimum alveolar concentration (MAC) are commonly used to monitor the depth of anesthesia. The objective was to study the correlation between BIS and age-adjusted minimum alveolar concentration (aaMAC ...
Nishant Kumar, Gunjan Bansal, Aruna Jain
doaj   +1 more source

Proton charge and magnetic rms radii from the elastic $ep$ scattering data

open access: yes, 2010
The elastic electron-proton scattering data are analysed in order to determine proton charge and magnetic rms radii, r_E and r_M. Along with the usual statistical error, we try to estimate a systematic error in the radii, caused by the inadequacy of ...
Arrington   +24 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Confirmatory Factor Analysis of the Structure of Statistics Anxiety Measure: An Examination of Four Alternative Models [PDF]

open access: yesIranian Journal of Psychiatry, 2011
Objective: The aim of this study is to explore the confirmatory factor analysis results of the Persian adaptation of Statistics Anxiety Measure (SAM), proposed by Earp.Method: The validity and reliability assessments of the scale were performed on 298 ...
Hossein Bevrani, PhD   +2 more
doaj  

On applications of the factor analysis in the agricultural research

open access: yesAgricultural Economics (AGRICECON), 2007
The authors give a brief overview of the outcomes of an application of the factor analysis and present results of two applications within the agricultural research.
V. Brabenec, H. Nešetřilová
doaj   +1 more source

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