Results 71 to 80 of about 3,572,018 (259)

Stochastic Period and Cohort Effect State-Space Mortality Models Incorporating Demographic Factors via Probabilistic Robust Principal Components

Risks, 2017
In this study we develop a multi-factor extension of the family of Lee-Carter stochastic mortality models. We build upon the time, period and cohort stochastic model structure to extend it to include exogenous observable demographic features that can be ...
Dorota Toczydlowska, Gareth W. Peters, Man Chung Fung, Pavel V. Shevchenko   +3 more
doaj   +1 more source

Finance chrétienne et finance musulmane

, 2011
Séance du 3 mars 2011 : Michèle Leclerc-Olive (CNRS-EHESS, IRIS) et Sylvain Piron (EHESS, CRH-GAS) Introduction par Michèle Leclerc-Olive : Quelques réflexions introductives pour aborder la finance islamique contemporaine Conférence de Sylvain Piron ...
Ethique et Finance
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Population and vital statistics report

, 2015
Report prepared and published by the Statistical Office, Central Planning Division, Ministry of Finance and Economic Planning of Saint Vincent and the Grenadines.
Saint Vincent and the Grenadines Statistical Office
core  

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Dynamics and forecasting of an age-structured stochastic SIR model with Lévy perturbations via physics-informed neural networks

Infectious Disease Modelling
Understanding and predicting real-world epidemic dynamics has consistently posed a formidable challenge. This study addresses an age-structured stochastic SIR model incorporating a general incidence rate, high-order white noise, and Lévy jump ...
Ge Zhang, Zhihao Wang, Zhiming Li, Shenglong Chen, Qiaoling Chen   +4 more
doaj   +1 more source

Statistical Inference of Odd Fréchet Inverse Lomax Distribution with Applications

Complexity, 2020
In this article, we propose and study a new three-parameter distribution, called the odd Fréchet inverse Lomax (OFIL) distribution, derived by combining the odd Fréchet-G family and the inverse Lomax distribution.
Ramadan A. ZeinEldin, Muhammad Ahsan ul Haq, Sharqa Hashmi, Mahmoud Elsehety, M. Elgarhy   +4 more
doaj   +1 more source

Population and vital statistics report

, 2016
Report prepared and published by the Statistical Office, Central Planning Division, Ministry of Finance and Economic Planning of Saint Vincent and the Grenadines.
Saint Vincent and the Grenadines Statistical Office
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source