Factors for Rituximab Refractoriness in AQP4‐IgG+ NMOSD: A Cohort Study
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune condition of the central nervous system (CNS), often associated with aquaporin‐4 antibodies (AQP4‐IgG). Rituximab, a CD20+ B‐cell depleting monoclonal antibody, is widely used as first‐line therapy.
Mariano Marrodan+8 more
wiley +1 more source
Coconut: covariate-assisted composite null hypothesis testing with applications to replicability analysis of high-throughput experimental data. [PDF]
Li Y, Li Y, Ma H, Yue Z, Zhang X.
europepmc +1 more source
Statistical hypothesis testing in intraspecific phylogeography: nested clade phylogeographical analysis vs. approximate Bayesian computation. [PDF]
Templeton AR.
europepmc +1 more source
Amyotrophic Lateral Sclerosis as a Multistep Process in the United States: A Population‐Based Study
ABSTRACT Background Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease that typically results in death within 3–5 years from symptom onset. However, little is known about the environmental exposures, clinical aspects, or social determinants of health factors that may be associated with the disease.
Jasmine Berry+7 more
wiley +1 more source
Rotation-invariance is essential for accurate detection of spatially variable genes in spatial transcriptomics. [PDF]
Su H, Cui Y.
europepmc +1 more source
Influence of Dystrophin Isoform Deficiency on Motor Development in Duchenne Muscular Dystrophy
ABSTRACT Objective In Duchenne muscular dystrophy (DMD), lack of the shorter dystrophin isoforms Dp140 and Dp71 is associated with increased central nervous system (CNS) involvement. We aimed to investigate how CNS involvement affects motor development in young DMD boys.
Mary Chesshyre+152 more
wiley +1 more source
Clinical trials with interim analyses: standardizing terminology to increase clarity. [PDF]
Asikanius E+7 more
europepmc +1 more source
Statistical hypothesis testing with time-frequency surrogates to check signal stationarity
C. Richard+5 more
semanticscholar +1 more source
ABSTRACT Objectives Cognitive disorders are common in older persons with seizures (PWS). Cognitive disorders are often associated with impaired Instrumental Activities of Daily Living (IADLs). However, the effects of seizures on IADLs remain unexplored.
Ifrah Zawar+5 more
wiley +1 more source
Updating statistical practice in ecotoxicology: reflections and recommendations. [PDF]
Moe SJ, Fox DR, Wolf R.
europepmc +1 more source