Results 21 to 30 of about 11,663 (227)

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

ATOMISTIC MODELLING OF MAGNETISATION REVERSAL PROCESSES IN RECORDING MEDIA [PDF]

, 2013
Magnetic materials used in the magnetic recording industry have been developed for several decades. However, since the areal recording desity is increased to around 1 Tbit/in2,some new physical challenges have become clear: particularly the need of using
Fan, Weijia
core  

First-Principles Statistical Mechanics Study of Magnetic Fluctuations and Order–Disorder in the Spinel LiNi0.5Mn1.5O4 Cathode [PDF]

While significant magnetic interactions exist in lithium transition metal oxides, commonly used as Li-ion cathodes, the interplay between magnetic couplings, disorder, and redox processes remains poorly understood.
Bassey, Euan N, Clément, Raphaële J, Behara, Sesha Sai, Van der Ven, Anton, Ponte, Graciela E García   +4 more
core   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Subspace system identification framework for the analysis of multimoded propagation of THz-transient signals

, 1990
We provide a system identification framework for the analysis of THz-transient data. The subspace identification algorithm for both deterministic and stochastic systems is used to model the time-domain responses of structures under broadband excitation ...
O’Donnell, Kane, Birch, David J.S., Xiang, P, Nan Li (155066), Mark A Williams, Chiu, WM, Riis, E., Laursen, Bo Wegge, I H Rodriguez, Martin, Robert W., Yokoyama Toshiyuki, Buric, Michael, C J Hogendoorn, Ling, HY, E N dos Santos, Steenhoven, AA Anton van, ,, Yip, Philip, Jones, J D C, Hossain, Md Moinul, Gardner, J. W., Zhu, HH, To, S, Ooi, A., Alex Attridge, Strain, K. A., Rodrigues, H., Tokmakov, K.V., Gao, X, Huang, QH, G W Baxter, Hogendoorn, C.J., MacPherson, W N, Janina Mazierska, Hunt, Neil T., P K C Wood, Dammalapati, U., Jin, W, Sun, Duo, Hadjiloucas, S., Zhao, D H, Yan, Zhang, Alessandro Salmi, Onuh, S., Rughoobur, Girish, Zhou, X., M J Da Silva, Paolo Minetola, Wang, Shanyuan, Carli L., Chrystie, R., Ju, BF, Mazierska, Janina, Ehmann, KF, Zhang, X, Cheng, L, Karolin, J., Williams, R. J., Zhang, M, Zhang, L, Nguyen, Danh, Zhang, H, Hui Xu (9203), Cree, Michael J., Jaroszynski, D.A., Cheng, X, P C Dastoor, O M H Rodriguez, Flockhart, G M H, Flockhart, Gordon M.H., Griffiths, H., Yong Yan, Sørensen, Thomas Just, Liffman, Kurt, Sidiroglou, Fotios, Birch, David J S, Yan, Yong, Guan, BO, Flewitt, AJ, Yin, JH, Xu, Hui, Williams, Mark A, Levi, R, Zhou, Kaiming, Dick, A.R., Cantatore, Angela, Choi, PC, Flewitt, Andrew J., Kaminski, C.F., Wynne, Klaas, Chen, Tong, Sutalo, Iiija, Carli, Lorenzo, Nand, Anbhawa, Pennella, Francesco, Yu, Tongxi, Yu, Winnie, Williams, M. A. (Mark A.), Guofeng Qiao (16049912), R Levi, Zhou Zhou (154603), Morbiducci U., Barbato, Giulio, Stewart, M., Yang, SM, Wood, Paul, Huang, Qing-Hua, F Sidiroglou, Flockhart, Gordon, Srinivasan, G., Flockhart, G, G Barbato, Gardner, JW, Harris, J., Walsh, Martin A., Bowen, J. W., , E., Thomas, Sanju, Jacob, M.V., Schiavi, A., Burns, I.S., Chen, Xianfeng, Md. Moinul Hossain, Perrone, Guido, David J S Birch, Maguire, L., Dong, Ming, Gardner, Julian W., Robb, G.R.M., Lau, Kin Tak, ROTINAT, René, Maklad, Mokhtar, Aldham, B., , F., Swinehart, Philip R, Bal, Harpreet Kaur, Tokmakov, Kirill, Cranch, G.A., Luca Iuliano, Chow, KW, Xu, DS, McLoskey, D., Li, Yi; id_orcid, Oishi, S., Yang, M, Xu, Di, MacPherson, William N.; id_orcid, Walker, Keith, Kaminski, C., Judd, Martin D., Tran, Y., Gao, Wei, Yang, Y, Tucker NP, Stewart, Martin, Hall, M., Lim, NY, Ren, MJ, Tosi, D., Becerra, Victor M., Genta, Gianfranco, McKenna, M., Chen, Zhong-Ping, Wang, SY, Krupka, Jerzy, Durst, F., Tucker, Nicholas P., McCartney, N., A A Van Steenhoven, Huang, Yan-Ping, 3156, 3155, Laursen, Bo W, Hoskisson, Paul A., Fan, S, Hua, T, Wu, YS, Borkowski, M., Barr, M., Popov, Ivan, Costa, N., Lee, WB, Barbosa, C., Fan, J, Zhang, Hui, Candelaresi M, Yang, Li, Li, Nan, Zheng, YP, 陈曦, L Carli, 3159, Whitenett, Gillian, 3158, 3157, Qiu, Huihe, Wang, Xiaoru, Zhou, Zhou, Ng, Sun-pui, 王小如, Hariharan, P., Ling, Hang Yin, Galvao, R. K. H., Fan, JT, Stewart, George, Lange, de, H.C., Takaya, Yasuhiro, Fernandes, C., Yu, T, Attridge, Alex, Baxter, Gregory W, Yu, W, Hourahine, B., Dotchev, Krassimir, Wang, Wei, ZHOU, Wei, HAMPEL, U., Strain, K.A., Villa-López, Farah-Helúe, Jones, J. D C, Hogendoorn, CJ Jankees, Apperson, Kathleen, Chow, Kwok Wing, Huihe Qiu, Hult, J., O'Hagan, W.J., Wan, X, Gao, Yongsheng, Fung, EHK, Li, Qingmin, , M., Araki Tsutomu, Kong, LB, 10324328, Parker, Anthony W., Demokan, MS, Guglielmone C., Kitcher, Daniel J, Danh Nguyen, Jamison, S.P., Xu, BG, P Hariharany, S F Collins, OMINI M., Robb, Kirsty, Guglielmone, C., G Genta, Xishi Wang, Ho, HL, Genta, G, H C De Lange, Dorrington, Adrian A., Tam, HY, Steenhoven, van, A.A., Varum, H., Jia, W., Parker AW, Levi, Raffaello, Xiao, J, Chen, Kevin P., Sagoo, K., McNeil, B.W.J., Lockerbie, Nicholas, Walsh MA, Hsu, C. T., Cheng, KW, K M O'Donnell, Xuan, HF, Esposito, E., Qiao, Guofeng, Galvao, Roberto K. H., O'Donnell, Kane, Bowen, John W., Tao, X, O'Connor, D., Wang, Shu-Zhe, Pennella F, S A Wade, Wang, Xishi, Hong, Fangjun, Salmi, Alessandro, Villa-López, Farah Helue, Carnegie, Dale A., Cain, M. G., Pei, HF, Lees, K., Ozawa, Y., Wang, H, Piner, Chris, Iuliano, Luca, Wang, L, Yoshimori Kyu, Wade, Scott A, Wang, S, Duan, W, Gough, W., Zhu, WL, MOULART, Raphaël, Li, David D U, Collins, Stephen F, Maier, R R J, Cheng, Li, Bennion, I, Yu, Hongbo, Becerra, V. M., Birch, David J. S., Krupka, J., Larmour, I. A., Robb K, Zheng, Yong-Ping, Payne, Andrew D., Knight, Alex E, Conroy, Richard M., Birch, David, Xin, Lingling, W Allison, Cantatore, A., De Chiffre L., Aoshima, S., Adamczyk, Katrin, Dastoor, P., Rolinski, Olaf J., Hong, CY, Zhu, Z, Candelaresi, Marco, He, YH, Culshaw, B., Z Brodzeli, Tao, XM, Fahy, A., Norris, I., He, Yong-Hong, Muniz-Piniella, A., De Chiffre, Leonardo, U Hampel, Lange, HC Rick de, Knight, Alex E., Li, J, Matsuda, K., Moodie, David, Li, H, Rosenberg, Martin, YAMAMOTO, Fujio, Li, C, Flockhart, G. M H, Watson, S., Hadjiloucas, Sillas, Guo, Guangmei, NISHIUMI, Toyohiko, McGuiness, C.D., Keating, M., Barton, J S, Wang, Xudong, SILVA, M. J. Da, SUZUKI, Takao, Kong, L, Cain, M., Olivero, Massimo, L De Chiffre, Infield, D.G., X J Zhou, Ng, SP, Karolin, Jan, Feng, J, Thomas, S, Nguyen, Thinh B, Li, Y, Johnstone, Walter, Qiu, H. H., Gumiero, Andrea, De Chiffre, L., Moinul Hossain, Md, McConnell, G., Cheng, Xiaoyin, Saito, Takayuki, Tao, Xiaoming, Kirkendall, C.K., Lu, MH, Morbiducci, Umberto, Birch, D.J.S., Choy, CL, Strigazzi, Alfredo, Birch, D. J. S., Zhao, Donghui, Maier, R. R J; id_orcid, Krystek, Michael, Pate, R.C., RODRIGUEZ, I. H., MacGregor, S.J., Thomas, O., Sommerfeld, M., Gang Lu, Zhang, Lin, Ferreira, L. A., Stewart, Hazel L, Manasseh, R., Chen, X F, Easton, C.D., Jerzy Krupka, Lau, KT, Rolinski, O.J., D J S Birch, Araújo, F. M., Huang, YP, Siew, W.H., Illesinghe, S., H K Bal, Qian, X, Ren, M, 91c9be23-1416-4160-ad4e-accfee1b658a, Papoff, F., Guo, T, Cole, Marina, Wei Wang (17594), Kumar, Jagadeesha, A Fahy, GUGLIELMONE, CLAUDIO LUIGI DOME, Yokoyama Shuko, Chen, ZP, Stewart , Hazel L., Carli, L., Guo, Y, Burns, D., SANTOS, E. N. dos, Hossain, Md. Moinul, Hegarty, T., Jayadevaiah, M., David Day-Uei Li (3954032), Chan, HLW, Vopson, Melvin, Chen, Xi, Sutter, Jens, Brodzeli, Zourab, Stanton, T., A Cantatore, Wiggins, Mark, Chen, YS, Chrystie, Robin S.M., Kar, F, Villa-López, FH, M Barr, Wang, DN, Lu, Gang, Stewart, G., Jagadeesha Kumar, Hoskisson PA, Chen, Y., Jones, Rhys, Barbato, G, Geddes, C.D., Graham, D., Adamczyk K, Wood, P. K. C., Costa, A., Bennion, Ian, Gumiero A, Rughoobur, G, Jones, D.R., Cheung, Amy, Minetola, Paolo, Cheung, CF, Sherrington, D.C., Choi, KF, Thomsen, L., Barton, James S., Yip , Philip, Atherton, K., Faulds, K., Omini, M., Lakshminarayanan, V., Thompson, S., Liao, Y, Sarkar, M, Schiavi A., Zhou, K M, Lockerbie, N.A., Burns, I., Sparavigna, Amelia Carolina, SCHIAVI, ALESSANDRO, Allison, W., Hunt NT, Cantatore A., Marshall, Joanna, RODRIGUEZ, O. M. H., Cole, M   +484 more
core   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Series of Concentration-Induced Phase Transitions in Cholesterol/Phosphatidylcholine Mixtures

, 2013
In lipid membranes, temperature-induced transition from gel-to-fluid phase increases the lateral diffusion of the lipid molecules by three orders of magnitude.
István P. Sugár, Parkson L.-G. Chong, Sugár, István P., Chong, Parkson L.-G., István Simon, Chong, Parkson Lee-Gau, Simon, István   +6 more
core   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source