Results 41 to 50 of about 64,533 (254)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Megasupramolecules for safer, cleaner fuel by end association of long telechelic polymers [PDF]

, 2015
We used statistical mechanics to design polymers that defy conventional wisdom by self-assembling into “megasupramolecules” (≥5000 kg/mol) at low concentration (≤0.3 weight percent).
David, R. L.Ameri, Jones, Simon C., Kornfield, Julia A., Li, Boyu, Sarohia, Virendra, Schmitigal, Joel A., Wei, Ming-Hsin   +6 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Multifractality and Freezing Phenomena in Random Energy Landscapes: an Introduction [PDF]

, 2010
The Boltzmann-Gibbs probability distributions generated by logarithmically correlated random potentials provide a simple yet nontrivial example of disorder-induced multifractal measures. We introduce and discuss two analytically tractable models for such
Bacry, Bacry, Ben Arous, Bolthausen, Bouchaud, Bovier, Bramson, Carpentier, Castillo, Chabra, Chamon, Crisanti, Daviaud, de Almeida, De Dominicis, Derrida, Derrida, Evers, Foster, Fyodorov, Fyodorov, Fyodorov, Fyodorov, Fyodorov, Fyodorov, Gardner, Gradshteyn, Kogan, Mandelbrot, Mezard, Monthus, Monthus, Muzy, Ostrovsky, Paladin, Percus, Saakian, Saakian, Schmitt, Schmitt, Van Kampen, Yan V. Fyodorov   +41 more
core   +1 more source

What Do Large Language Models Know About Materials?

Advanced Engineering Materials, EarlyView.
If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer, Thomas Wallmersperger, Gianaurelio Cuniberti   +2 more
wiley   +1 more source

On Growth, Disorder, and Field Theory

, 1998
This article reviews recent developments in statistical field theory far from equilibrium. It focuses on the Kardar-Parisi-Zhang equation of stochastic surface growth and its mathematical relatives, namely the stochastic Burgers equation in fluid ...
Ala-Nissila T, Balents L, Bausch R, Cardy J L, Chekhlov A, Cook J, Cook J, de Gennes P G, Drasdo D, Drasdo D, Evans M R, Forgacs G, Hwa T, Hwa T, Hwa T, Imbrie J Z, Itzykson C, Kim J M, Kinzelbach H, Kolmogorov A, Krug J, Krug J, Lipowsky R, Lässig M, Lässig M, Lässig M, Lässig M, Maunuksela J, Meakin P, Michael Lässig, Mukherji S, Mézard M, Mézard M, Nattermann T, Nattermann T, Olsen R, Rajasekaran J J, Tang L-H, van Dijken S, Wiese K J, Willbrand K, Wolf D, Zhang Y-C   +42 more
core   +3 more sources

On Renormalization Group Flows and Polymer Algebras [PDF]

, 1994
In this talk methods for a rigorous control of the renormalization group (RG) flow of field theories are discussed. The RG equations involve the flow of an infinite number of local partition functions.
A. Pordt, C. Gruber, D. Brydges, G. Felder, G. Mack, G. Mack, H. Koch, H. Koch, J. Dimock, J. Dimock, J. Dimock, J. Feldman, J. Gawędzki, J. Glimm, J. Glimm, J. Magnen, K. G. Wilson, K. G. Wilson, K. G. Wilson, K. Gawędzki, K. Gawędzki, P. Collet, P. Collet, T. Balaban, T. Balaban, T. L. Bell   +25 more
core   +3 more sources

Statistical mechanics of polymer systems. Final [PDF]

, 1993
Work on computer simulation of polymer dynamics and the statistical mechanics of quenched systems carried out over seven years with the support of this grant is reviewed. The computer simulation work has focused on elucidation the roles of the excluded volume and the nearest-neighbor attractive interactions in the dynamics of polymers.
openaire   +2 more sources

Synthesis of a Novel Thermoresponsive S53P4 Bioactive Glass Extract–Poloxamer 407 Injectable Hydrogels: Assessment of Biocompatibility and Antimicrobial Properties

Advanced Engineering Materials, EarlyView.
This study investigates innovative thermoreversible hydrogels derived from S53P4 bioactive glass extracts to aid in the healing of infected diabetic foot wounds. These injectable gels, which gel at body temperature, release beneficial ions and remain stable over time.
Marian G. Vargas Guerrero, Adrian Stiller, Alex Nygård, Matej Krivulka, Lars Galema, Erwin Peters, Jimmy Lucchesi, Peter Uppstu, Leena Hupa, Jacobus J. C. Arts   +9 more
wiley   +1 more source

Prediction of Surface Topography Parameters in Direct Laser Interference Patterning of Stainless Steel Using Infrared Monitoring and Convolutional Neural Networks

Advanced Engineering Materials, EarlyView.
This study presents an infrared monitoring approach for direct laser interference patterning (DLIP) combined with a convolutional neural network (CNN). Thermal emission data captured during structuring are used to predict surface topography parameters.
Lukas Olawsky, Marcelo Sallese, Leander Kläber, Clemens Kuhn, Keming Du, Andrés Fabián Lasagni   +5 more
wiley   +1 more source