Results 121 to 130 of about 342,758 (257)

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

open access: yesAdvanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang   +12 more
wiley   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

open access: yesAdvanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian   +11 more
wiley   +1 more source

Assessing Development Degree and Ranking Townships of Mazandaran Province by Using Factor Analysis and Cluster Analysis

open access: yesجغرافیا و برنامه‌ریزی محیطی, 2013
Extended abstract1- Introduction Regional planning aiming at promoting development and decreasing inequality is considered among important issues in developing countries.
M. Taghvaei, I. Bahari
doaj  

Identification and green grading of jobs in the renewable energy field of the biomass: A grounded theory study

open access: yesSalāmat-i kār-i Īrān, 2020
Background and aims: Fossil fuels Emission and their limited resources make to use renewable energy with more sustainable energy sources and less minimal environmental impacts.
ladan razikordmahaleh, maryam larijani
doaj  

Extreme Value Theory and the Incidence of Currency Crises [PDF]

open access: yes
A common feature of numerous studies on early warning systems (EWS) of currency crisis is the use of an index of exchange market pressure, defined as a weighted average of the rate of depreciation, the monthly percentage changes in international reserves,
Ramkishen Rajan,   +2 more
core  

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

open access: yesAdvanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei   +9 more
wiley   +1 more source

Inference on Income Inequality and Tax Progressivity Indices: U-Statistics and Bootstrap Methods [PDF]

open access: yes
This paper discusses asymptotic and bootstrap inference methods for a set of inequality and progressivity indices. The application of non-degenerate U-statistics theory is described, particularly through the derivation of the Suits-progressivity index ...
Raquel Andres, Samuel Calonge
core  

Coupling Nitrogenous Organic Wastewater Treatment and Biorefinery via N‐Cycling Bacterium

open access: yesAdvanced Science, EarlyView.
The vast reservoir of nitrogenous organic pollutants in industrial wastewaters can serve as untapped carbon‐nitrogen resources. This study employs the newly discovered Paracoccus sp. ZQW‐1 as a versatile chassis to simultaneously achieve N‐methylpyrrolidone (NMP) wastewater depuration and polyhydroxybutyrate (PHB) synthesis.
Ziqian Wang   +3 more
wiley   +1 more source

TIPs for the Analysis of Poverty in Mexico, 1992-2005 [PDF]

open access: yes
This paper proposes some changes to the official methodology that is currently in use to measure the state of poverty in Mexico. Among other suggestions, it is recommended the use of bootstrapping to estimate confidence intervals for the poverty ...
Macías, Alejandra   +2 more
core  

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