Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Effects of different telehabilitation methods on postoperative pulmonary rehabilitation of patients with lung cancer: a systematic review and network meta-analysis of randomised controlled trials protocol. [PDF]
Liu J, Niu H, Li J, Chen Q, Bi H.
europepmc +1 more source
Preserving edits when perturbing microdata for statistical disclosure control
To protect individuals in microdata from the risk of re-identification, a general perturbative method called PRAM (the Post-Randomization Method) is sometimes used for masking records.
Ntalie Shlomo +3 more
core
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Exploring causal correlations between oily fish intake and multiple sclerosis: A two-sample Mendelian randomization study. [PDF]
Chang S, Shi K, Zhang M.
europepmc +1 more source
Are these data real? Statistical methods for the detection of data fabrication in clinical trials
Sanaa Al-Marzouki +3 more
semanticscholar +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Meta-analysis of 633,317 individuals shows associations between healthy diets and depression, anxiety and stress in 23 low- and middle-income countries. [PDF]
Sparling TM +4 more
europepmc +1 more source
Outliers in Garch models and the estimation of risk measures [PDF]
In this paper we focus on the impact of additive level outliers on the calculation of risk measures, such as minimum capital risk requirements, and compare four alternatives of reducing these measures' estimation biases. The first three proposals proceed
Aurea Grané, Helena Veiga
core

