Results 251 to 260 of about 775,359 (318)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Author Correction: Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning. [PDF]

Nat Commun
Chen JZ, Bisardi M, Lee D, Cotogno S, Zamponi F, Weigt M, Tokuriki N.   +6 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Quantification and statistical modeling of droplet-based single-nucleus RNA-sequencing data. [PDF]

Biostatistics
Kuo A, Hansen KD, Hicks SC.
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Statistical modeling and optimization of volatile fatty acids production by anaerobic digestion of municipal wastewater sludge. [PDF]

Environ Sci Pollut Res Int
Gracia J, Acevedo O, Acevedo P, Mosquera J, Montenegro C, Cabeza I.   +5 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Understanding epistatic networks in the B1 β-lactamases through coevolutionary statistical modeling and deep mutational scanning. [PDF]

Nat Commun
Chen JZ, Bisardi M, Lee D, Cotogno S, Zamponi F, Weigt M, Tokuriki N.   +6 more
europepmc   +1 more source

Exploiting relationship directionality to enhance statistical modeling of peer-influence across social networks. [PDF]

Stat Med
Ran X, Morden NE, Meara E, Moen EL, Rockmore DN, O'Malley AJ.   +5 more
europepmc   +1 more source

Identifying Variables Influencing Traditional Food Solid-State Fermentation by Statistical Modeling. [PDF]

Foods
Jin G, Boeschoten S, Hageman J, Zhu Y, Wijffels R, Rinzema A, Xu Y.   +6 more
europepmc   +1 more source