Results 111 to 120 of about 4,326,503 (305)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Modelling the Measles Outbreak at Hong Kong International Airport in 2019: A Data-Driven Analysis on the Effects of Timely Reporting and Public Awareness

Infection and Drug Resistance, 2020
Shi Zhao,1,2,* Xiujuan Tang,3,* Xue Liang,4,* Marc KC Chong,1,2 Jinjun Ran,5 Salihu S Musa,6 Guangpu Yang,7 Peihua Cao,8 Kai Wang,9 Benny CY Zee,1,2 Xin Wang,3 Daihai He,6 Maggie H Wang1,2 1Division of Biostatistics, JC School of Public Health and ...
Zhao S, Tang X, Liang X, Chong MKC, Ran J, Musa SS, Yang G, Cao P, Wang K, Zee BCY, Wang X, He D, Wang MH   +12 more
doaj  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Editorial for the special issue: “Advances and Trends in Post-transition Countries: Statistical Modelling Approach”

Business Systems Research, 2019
This special issue of Business Systems Research is highlights recent advances and trends in post-transition countries, taking into account statistical modelling approach. Nine papers that have been selected for this special issue present improvements and
Dumičić Ksenija, Novkovska Blagica, Resić Emina   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Editorial: Predicting high-risk individuals for common diseases using multi-omics and epidemiological data, volume II

Frontiers in Genetics, 2023
Werner P. Veldsman, Xin Maizie Zhou, YuanWei Zhang, YuanWei Zhang, Bailiang Li, Lu Zhang   +5 more
doaj   +1 more source

Insecticide-treated net use and elimination of malaria in Sub-Saharan African countries: assessing the Global Technical Strategy using an evolutionary game approach

BMC Infectious Diseases
Background Malaria continues to be a major public health challenge in Sub-Saharan Africa (SSA), where the majority of the countries have not met the World Health Assembly’s endorsed Global Technical Strategy (GTS) milestones in 2020 for malaria reduction.
Laxmi, Tamer Oraby, Michael G. Tyshenko, Ina Danquah, Samit Bhattacharyya   +4 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Cultural traits may replace human mobility data in forecasting COVID-19 mortality: a deep learning approach

Machine Learning: Health
The COVID-19 pandemic highlighted the need for accurate epidemic forecasting to support public health decision-making. Most existing approaches depend heavily on human mobility data, while largely neglecting population behavior shaped by socio-cultural ...
Saif Abbas, Tamer Oraby, Michael G Tyshenko, Samit Bhattacharyya   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source