Results 201 to 210 of about 4,326,503 (305)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Decoding Fear: Analysis and Prognosis of Preoperatory Stress Level Through Advanced Statistical Modelling-A Prospective Study Across Multiple Surgical Specialties. [PDF]

Med Sci (Basel)
Dascălu CG, Cucu AI, Vovciuc A, Axinte S, Turliuc S, Bobu AM, Tamas C, Porumb V, Patrascanu E, Buzduga CM, Blanaru PA, Morosan AP, Prutianu I, Covali R, Pruteanu AI, Costea CF, Carauleanu A.   +16 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Using statistical modelling and machine learning in detecting bone properties: A systematic review protocol. [PDF]

PLoS One
Abdelhay O, Alshoubaki R, Murad S, Abdel-Hafez O, Abdelhay Q, Haddad B, Alhosanie T, Ajlouni H, Ajlouni L, Qarain T, Murad H, Altamimi T.   +11 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Decomposing unaccusativity: a statistical modelling approach. [PDF]

Lang Cogn Neurosci
Kim S, Binder JR, Humphries C, Conant LL.   +3 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Changes in influenza-associated excess mortality in China between 2012-2019 and 2020-2021: a population-based statistical modelling study. [PDF]

Infect Dis Poverty
Deng X, Liu J, Wang M, Chen N, Hao F, Yang J, Zhou M, Yu H.   +7 more
europepmc   +1 more source

The seasonality of cholera in sub-Saharan Africa: a statistical modelling study.

Lancet Glob Health, 2022
Perez-Saez J, Lessler J, Lee EC, Luquero FJ, Malembaka EB, Finger F, Langa JP, Yennan S, Zaitchik B, Azman AS.   +9 more
europepmc   +1 more source