Results 61 to 70 of about 4,326,503 (305)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Computational Lower Limb Simulator Boundary Conditions to Reproduce Measured TKA Loading in a Cohort of Telemetric Implant Patients

Bioengineering
Recent advancements in computational modeling offer opportunities to refine total knee arthroplasty (TKA) design and treatment strategies. This study developed patient-specific simulator external boundary conditions (EBCs) using a PID-controlled lower ...
Chase Maag, Clare K. Fitzpatrick, Paul J. Rullkoetter   +2 more
doaj   +1 more source

Inference for Convolutionally Observed Diffusion Processes

Entropy, 2020
We propose a new statistical observation scheme of diffusion processes named convolutional observation, where it is possible to deal with smoother observation than ordinary diffusion processes by considering convolution of diffusion processes and some ...
Shogo H Nakakita, Masayuki Uchida
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

An approach to determine clusters overlap for k-means clustering

, 2015
Clustering is one of the major and interesting tools for many data analysis in business, science, medical, social network and other sources. Various clustering methods are available and applied in different fields, but unfortunately they are still ...
Matawie, Kenan M. (R8147), Maeder, Anthony (R13343), Muhammad, Arshad M. (S27871)   +2 more
core  

Multivariate Hierarchical Modelling of Household Air Pollution [PDF]

, 2019
This is the author accepted manuscript. The final version is available from the Statistical Modelling Society via the link in this recordExposure to household air pollution has been attributed to an estimated 3.8 million deaths per year.
Shaddick, G, Economou, T, Stoner, OR, Ruggeri, G, Lewis, J, Lucio, I, Adair-Rohani, H, Gumy, S   +7 more
core  

Clinical relevance of CompEx Asthma and impact on disease trajectory: benralizumab effect

ERJ Open Research
Background Severe exacerbations (SevEx), the typical endpoint when evaluating asthma therapies, may provide incomplete assessment, as it relies on patient perception of disease and physician action.
Clare Bolton, Praveen Akuthota, Njira Lugogo, Peter Barker, Thomas Bengtsson, Stefan Peterson, Salman Siddiqui, Carla A. Da Silva   +7 more
doaj   +1 more source

Statistical Modelling of Global Tectonic Activity and some Physical Consequences of its Results [PDF]

Journal of Systemics, Cybernetics and Informatics, 2015
Based on the analysis of global earthquake data bank for the last thirty years, a global tectonic activity indicator was proposed comprising a weekly globally averaged mean earthquake magnitude value.
Konstantin Statnikov, Gregory Kruchenitsky   +1 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source