Results 141 to 150 of about 6,852,071 (351)

Statistical methods in grape and wine research for quantifying the impact of climate change

open access: yesOENO One
Studies analysing the impact that climate change could have on the wine sector are important for determining appropriate adaptation strategies. Statistical methods provide a useful approach for estimating future climate impacts.
German Puga, Kym Anderson
doaj   +1 more source

Statistical Inference with Data Augmentation and Parameter Expansion [PDF]

open access: yesarXiv, 2015
Statistical pragmatism embraces all efficient methods in statistical inference. Augmentation of the collected data is used herein to obtain representative population information from a large class of non-representative population's units. Parameter expansion of a probability model is shown to reduce the upper bound on the sum of error probabilities for
arxiv  

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Adaptive Statistical Evaluation Tools for Equity Ranking Models [PDF]

open access: yes, 2005
A major challenge in the investment management business is to identify which stocks are likely to outperform in the future, and which are likely to perform relatively poorly.
Ware, Tony
core  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Longevity and statistical modelling [PDF]

open access: yes, 2020
This dissertation consists of two studies on the modelling aspects of mortality (or longevity). In the first paper, we examine cohort extensions of the Poisson common factor model for modelling mortality of both genders jointly. Several alternatives are specified and applied to datasets from five developed regions.
openaire   +3 more sources

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