Background While treat‐to‐target urate‐lowering therapy (ULT) is endorsed as best practice in gout management, limited data exist on its impact on health‐related quality of life (HRQoL). We assessed the impact of treat‐to‐target ULT on HRQoL among participants receiving protocolized gout care, identifying factors associated with HRQoL and HRQoL change.
Austin Barry+16 more
wiley +1 more source
Editorial: Negative and positive data, statistical power, and confidence intervals [PDF]
David A. Andow
openalex +1 more source
Chronic Opioids in Gout: A Matched Cohort Study from the Veteran's Health Administration
Objective Though used frequently to treat flare, risk of chronic opioid exposure in gout has not been well defined. In this study, we examined the hypothesis that people with gout are more likely than individuals without gout to be prescribed chronic opioids over time.
Lindsay N. Helget+7 more
wiley +1 more source
RETR_PWR: An SAS macro for retrospective statistical power analysis [PDF]
Kristine Y. Hogarty, Jeffrey D. Kromrey
openalex +1 more source
Summary Data‐driven forecasting of ship motions in waves is investigated through feedforward and recurrent neural networks as well as dynamic mode decomposition. The goal is to predict future ship motion variables based on past data collected on the field, using equation‐free approaches.
Matteo Diez+2 more
wiley +1 more source
Are most published research findings false? Trends in statistical power, publication selection bias, and the false discovery rate in psychology (1975-2017). [PDF]
Schneck A.
europepmc +1 more source
Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe+4 more
wiley +1 more source
Statistical power and false positive rates for interdependent outcomes are strongly influenced by test type: Implications for behavioral neuroscience. [PDF]
Frankot M+3 more
europepmc +1 more source
Power Comparison of EGLS Test Statistic for Fixed Effects with Arbitrary Distributions [PDF]
Jang-Taek Lee
openalex +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio+11 more
wiley +1 more source