Results 181 to 190 of about 2,369,265 (290)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Site-Specific Assessment of Statistical Process Control to Set Tolerance and Action Limits for Patient-Specific Quality Assurance in RapidArc Treatment Delivery. [PDF]

J Biomed Phys Eng
Manna S, Singh BK, Das KJM.
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Statistical Process Control

Statistical process control methodology was developed by Walter Shewhart in the 1920s as part of his work on quality control in industry. Shewhart observed that quality is about hitting target specifications with minimum variation. While every process is subject to variation, that variation can arise from 'common cause' variation, inherent in the ...
openaire   +1 more source

Long-term performance evaluation of a 1.5T MR-Linac using statistical process control techniques. [PDF]

Radiat Oncol
Xiao Q, Shen M, Li G, Zhu S, He J, Wang Q, Dai G, Yu H, Lai J, Zhong R, Bai S.   +10 more
europepmc   +1 more source

Quality Management of Head and Neck patient treatment using Statistical Process Control techniques

, 2023
Sandford M, Steel JG, Goodworth J, Lodge P.   +3 more
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Statistical Process Control - A Well Kept Secret

Measurement + Control, 1995
doaj   +1 more source

Cluster randomised evaluation of a training intervention to increase the use of statistical process control charts for hospitals in England: making data count. [PDF]

BMJ Qual Saf
Schmidtke KA, Kudrna L, Quinn L, Bird P, Hemming K, Venable Z, Lilford R.   +6 more
europepmc   +1 more source

Computing Multivariate Process Capability Indices With Microsoft Excel

In manufacturing industry there is growing interest in measures of process capability under multivariate setting. While there are many statistical packages to assess univariate capability, a current problem with the multivariate measures of capability is
Michele Scagliarini, Raffaele Vermiglio
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