Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
MULTIVARIATE STATISTICAL TECHNIQUES FOR QUALITY CONTROL AND PROCESS MONITORING
Sohail Anwer,Rana Waseem Ahmad,Faisal Afzal Siddiqui,Rida Ameen,Wali Rehman
openalex +1 more source
IMPLEMENTATION OF STATISTICAL PROCESS CONTROL (SPC) FOR MANUFACTURING PERFORMANCE IMPROVEMENT
, 1970 S. Farzana +2 more
openalex +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Use of optimised dual statistical process control charts for early detection of surgical site infection outbreaks. [PDF]
BMJ Qual Saf, 2020 Baker AW +4 more
europepmc +1 more source
Rancangan Statistical Process Control (SPC) Pada CV. Marga Mulya, Surabaya [PDF]
, 2015 Freddy Raharjo
openalex
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Determination of machine-specific tolerances using statistical process control analysis of long-term uniform scanning proton machine QA results. [PDF]
J Appl Clin Med Phys, 2020 Rana S +6 more
europepmc +1 more source