Results 81 to 90 of about 5,875,188 (336)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

open access: yesFEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Statistical process control and interrupted time series: a golden opportunity for impact evaluation in quality improvement

open access: yesBMJ Quality & Safety, 2015
Time series plots are widely used, across sectors and media, probably because many find them easy to understand. Figure 1 is a time series plot of how the readmission rate in a hospital changed over time (constructed data set).
A. Fretheim, Oliver Tomic
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Application of Machine Learning in Statistical Process Control Charts: A Survey and Perspective

open access: yesSpringer Series in Reliability Engineering, 2021
P. H. Tran   +4 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

An Excel Add-In for Statistical Process Control Charts

open access: yesJournal of Statistical Software, 2009
t shifts in processes in, for example, manufacturing. Among these are control charts".Control charts and other SPC techniques have been in use since at least the 1950s, and,because they are comparatively unsophisticated, are often used by management or ...
Samuel E. Buttrey
doaj  

The Contribution of Variable Control Charts to Quality Improvement in Healthcare: A Literature Review

open access: yesJournal of Healthcare Leadership, 2021
Line Slyngstad Molde University College, Molde, 6410, NorwayCorrespondence: Line SlyngstadMolde University College, Britvegen 2, Molde, 6410, NorwayTel +47 71214226Email line.slyngstad@himolde.noObjective: To conduct a literature review to determine ...
Slyngstad L
doaj  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

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