Results 171 to 180 of about 573,105 (295)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A first-of-its-kind two-body statistical shape model of the arthropathic shoulder: enhancing biomechanics and surgical planning. [PDF]

J Orthop Surg Res
Blackman J, Giles JW.
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Automatic virtual reconstruction of acetabular fractures using a statistical shape model. [PDF]

Eur J Trauma Emerg Surg
van Veldhuizen WA, van Noortwijk R, Meesters A, Duis KT, Schuurmann R, de Vries J, Wolterink JM, IJpma F.   +7 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

OpenHands: An Open-Source Statistical Shape Model of the Finger Bones. [PDF]

Ann Biomed Eng
Munyebvu TA, Metcalf CD, Burson-Thomas CB, Warwick D, Everitt C, King L, Darekar A, Browne M, Heller MOW, Dickinson AS.   +9 more
europepmc   +1 more source

Combining Statistical Shape Model and Principal Component Analysis to Estimate Left Ventricular Volume and Ejection Fraction. [PDF]

Proc SPIE Int Soc Opt Eng, 2020
Liu D, Dangi S, Schwarz KQ, Linte CA.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A 3D Statistical Shape Model Of The Pelvic Bone For Segmentation

, 2008
Statistical models of shape are a promising approach for robust and automatic segmentation of medical image data. This work describes the construction of a statistical shape model of the pelvic bone.
Hans Lamecker A, Hans-christian Hege A, Martin Seebaß B, Peter Deuflhard A   +3 more
core