Results 231 to 240 of about 573,105 (295)

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Is a standardised severity index needed in unicoronal craniosynostosis? Challenges in developing an objective metric. [PDF]

Childs Nerv Syst
van der Straeten R, Lif H, Geoffroy M, Taverne M, Paternoster G, Laporte S, Khonsari RH.   +6 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Combination of tissue-derived and shape-based parameters for subclinical keratoconus detection. [PDF]

Biomed Opt Express
Casado-Moreno J, Arizcuren AR, Rozema JJ, Consejo A.   +3 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Population-specific statistical shape modeling of the Japanese shoulder: a combined analysis of the scapula and humerus stratified by sex and stature. [PDF]

JSES Int
Iio R, Blackman J, Spangenberg GW, Oi N, Ito Y, Johnson JA, Athwal GS, Giles JW.   +7 more
europepmc   +1 more source

Asymmetric Cavovarus Deformity Presentation in Charcot-Marie-Tooth Disease. [PDF]

Foot Ankle Orthop
Requist MR, Peterson AC, Chrea B, Lenz AL.   +3 more
europepmc   +1 more source

An extended exponentiated F distribution with theoretical properties and application to lung survival analysis. [PDF]

Sci Rep
Aldhufairi FAA.
europepmc   +1 more source

Comparison of two regression techniques for statistical shape model based reconstruction: Application to the proximal femur and the pelvis

, 2011
Schumann, Steffen, Nolte, Lutz-Peter, Zheng Guoyan,   +2 more
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