Results 191 to 200 of about 440,224 (250)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Population-specific statistical shape modeling of the Japanese shoulder: a combined analysis of the scapula and humerus stratified by sex and stature. [PDF]

JSES Int
Iio R, Blackman J, Spangenberg GW, Oi N, Ito Y, Johnson JA, Athwal GS, Giles JW.   +7 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Mesoscopic Modeling of Fracture in Heterogeneous Bituminous Polymer Composites: Coupling Random Aggregate Distribution with Bilinear Cohesive Zone Models. [PDF]

Polymers (Basel)
Li W, Gao H, Xie L, Tan Z, Cao P.
europepmc   +1 more source

Mesial temporal shape asymmetry as a neuro-imaging correlate of epilepsy in mild cognitive impairment and dementia. [PDF]

Brain Commun
Zawar I, Zhu S, Quigg M, Kapur J, Lam AD, Sarkis RA, D'Abreu A, Manning C, Fletcher PT.   +8 more
europepmc   +1 more source

Methodological Issues Related to the Reported Association of A Body Shape Index With Abdominal Aortic Calcification in Patients With Hypertension. [PDF]

Clin Cardiol
Shahab L, Khan SH, Zain JK.
europepmc   +1 more source

Combination of tissue-derived and shape-based parameters for subclinical keratoconus detection. [PDF]

Biomed Opt Express
Casado-Moreno J, Arizcuren AR, Rozema JJ, Consejo A.   +3 more
europepmc   +1 more source

Evaluating the Ability of Multimodal Artificial Intelligence to Identify Endodontic Instruments: A Comparative Study of ChatGPT-4o and Gemini 3 Flash. [PDF]

J Clin Med
Tosun S, Çulha E.
europepmc   +1 more source

Discriminative and predictive power of radiomics features from preoperative MRI studies in patients with supraspinatus lesions. [PDF]

BMC Musculoskelet Disord
Longo UG, Giaccone P, Bacco L, D'Antoni F, Lalli A, Bandini B, di Naro C, Casciaro C, Nazarian A, Merone M, Schena E, Papalia R.   +11 more
europepmc   +1 more source