Results 231 to 240 of about 12,459,906 (292)

A Semi-Automated Imaging Flow Cytometry Workflow for High-Throughput Quantification of Compound Internalization with IDEAS and FluoSta Software. [PDF]

Methods Protoc
Elfimov K, Gotfrid L, Nokhova A, Gashnikova M, Baboshko D, Totmenin A, Agaphonov A, Gashnikova N.   +7 more
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Rate constants for a reactive system of astrophysical interest: a statistical study of CH₂^.

Phys Chem Chem Phys
González-Lezana T, Konings M, Loreau J, Lique F, Sil M, Faure A.   +5 more
europepmc   +1 more source

Simple, Fast, and Reliable Analysis of Label-Free Proteomics Data With the Proteomics Eye (ProtE). [PDF]

Proteomics Clin Appl
Margelos T, Makridakis M, Gonidaki C, Paradeisi F, Vossos M, Zoidakis J, Vlahou A, Stroggilos R.   +7 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Apolipoprotein E drives microglia activation in the development of autoimmune uveitis through up-regulation of peptidyl prolyl isomerase F. [PDF]

Sci Adv
Zeng S, Wang Y, Liu X, Feng H, Cao F, Chu B, Wu C, Fan W, Hu K, Lei F, Hou S.   +10 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

An integrated graph neural network model for joint software defect prediction and code quality assessment. [PDF]

Sci Rep
Dai P, Zhu H, Wu J, He H.
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

macpie: Scalable workflow for high-throughput transcriptomic profiling. [PDF]

Comput Struct Biotechnol J
Bartonicek N, Liu X, Twomey L, Meier M, Lupat R, Craig S, Yoannidis D, Li J, Semple T, Simpson KJ, Li MX, Ramm S.   +11 more
europepmc   +1 more source