Results 201 to 210 of about 4,661,962 (244)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Analysis of Bond Strength of Bioceramic Sealer Following Irrigation with Chlorhexidine. [PDF]

Iran Endod J
Costa LG, Saldanha JM, da Silva-Filho JE, Aguiar BA, de Almeida Gomes F, Gurgel-Filho ED.   +5 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A Multi-Criterion Selection of Hybrid Features in Mammographic Imaging for Early Computer-Assisted Sensing and Detection of Breast Cancer. [PDF]

Sensors (Basel)
Zaylaa AJ, Yassine LN, Kourtian S.
europepmc   +1 more source

Pathogenic mutations in clathrin heavy chain disrupt synapse architecture and learning in <i>Drosophila</i>. [PDF]

iScience
Das J, Datta M, Pippadpally S, Jethani B, Singh SB, Kshirsagar A, Jena A, Kumar V, Majumdar A, Subramanyam D.   +9 more
europepmc   +1 more source

Kumskova M, Flora GD, Nayak MK, et al. Platelet defects in patients and mice with Ehlers-Danlos syndrome. Blood. 2026;147(9):987-997.

Blood
europepmc   +1 more source

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The Statistical Sign Test

Journal of the American Statistical Association, 1946
Abstract This paper presents and illustrates a simple statistical test for judging whether one of two materials or treatments is better than the other. The data to which the test is applied consist of paired observations on the two materials or treatments. The test is based on the signs of the differences between the pairs of observations.
W J, DIXON, A M, MOOD
openaire   +2 more sources