Variant Calling in the Goldilocks Zone: How Reference Genome Choice and Read Mapping Stringency Impact Heterozygosity Estimates and Phylogenetic Analyses. [PDF]
Mohn RA, Garner M, Manos PS, Hipp AL.
europepmc +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Understanding rice production stagnation in the Philippines: Regional evidence and development implications. [PDF]
Bartelet HA +3 more
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Interpretability and variability of metamodel validation statistics in engineering system design optimization: a practical study [PDF]
Husam Hamad, Awad Al‐Zaben, Rami Owies
openalex +1 more source
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Do undergraduate psychology statistics textbooks make connections to their underlying epistemological basis? [PDF]
Kingston NM +3 more
europepmc +1 more source
Bayesian vs frequentist statistics: afraid of losing the reference?
Ignacio Ferreira‐González +1 more
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The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat +18 more
wiley +1 more source
Dynamic links between economic complexity, technological innovation, structural transformation and energy sustainability in newly industrializing countries. [PDF]
Zirui Y, Mao J, Li Y.
europepmc +1 more source

