Results 41 to 50 of about 2,607,281 (315)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Mendelian randomization: A biologist's perspective

Journal of the Practice of Cardiovascular Sciences, 2016
Mendelian randomization (MR) is a statistical technique used by genetic epidemiologists to determine causal effects, i.e. whether a biomarker actually influences disease risk, is it just a statistical association.
Subhoshree Ghose, Akash Kumar Bhaskar, Anju Sharma, Shantanu Sengupta   +3 more
doaj   +1 more source

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Recording of Alcohol in Official Crash Statistics: Underreporting and Procedures to Improve Statistics

Journal of Road Safety, 2018
Worldwide 1.25 million people die in road crashes every year and it is widely recognized that drink driving is an important risk-increasing factor. Official statistics of alcohol-related crashes are likely to underestimate alcohol-related crashes and ...
Luuk Vissers, Sjoerd Houwing, Fred Wegman   +2 more
doaj  

Active learning in research methods classes is associated with higher knowledge and confidence, though not evaluations or satisfaction

Frontiers in Psychology, 2016
Research methods and statistics are regarded as difficult subjects to teach, fueling investigations into techniques that increase student engagement.
Peter James Allen, Frank Daniel Baughman
doaj   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

SIDUR: formulación de un sistema de información con uso de vocabulario controlado orientado a la caracterización y muestreo de la población con y sin discapacidad, atendida por las prácticas de los programas de Rehabilitación, Universidad del Rosario

Revista Ciencias de la Salud, 2010
Introduction: the statistical record used in the Field Academic Programs (PAC for it’s initials in Spanish) of Rehabilitation denotesgeneralities in the data conceptualization, which complicates thereliable guidance in making decisions and provides a low
Nathalia Ortega Martínez, Sandra Pulido Sánchez   +1 more
doaj  

Theoretical Re-evaluations of Scaling Relations between SMBHs and Their Host Galaxies–2. Importance of AGN Feedback Suggested by Stellar Age–Velocity Dispersion Relation

Frontiers in Astronomy and Space Sciences, 2017
We present the galactic stellar age—velocity dispersion relation obtained from a semi-analytic model of galaxy formation. We divide galaxies into two populations: galaxies which have over-massive/under-massive black holes (BHs) against the best-fitting ...
Hikari Shirakata, Toshihiro Kawaguchi, Takashi Okamoto, Tomoaki Ishiyama   +3 more
doaj   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source