Results 111 to 120 of about 813,688 (256)

Cross-Ancestry Polygenic Prediction: Comparing Methods and Assessing Transferability Across Traits. [PDF]

Genet Epidemiol
Momin MM, Zhou X, Ahmed M, Hyppönen E, Benyamin B, Lee SH.   +5 more
europepmc   +1 more source

Significant Role of Statistics in Computational Sciences

, 2015
Rakesh Kumar Singh, Neeraj Tiwari, R. C. Prasad   +2 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Computational Statistics [PDF]

, 2009
openaire   +2 more sources

Do hotel green practices influence customer satisfaction? Evidence from the Indian hospitality sector. [PDF]

F1000Res
Singh AK, Poddar AK, Kumar S, Dahiya M, Dashora AK, Kumar S, Paatlan S, Sharma A, Bakshi N, Singh AK.   +9 more
europepmc   +1 more source

Computational Statistics with Dummy Variables

, 2022
Adji Achmad Rinaldo Fernandes, Solimun Solimun, Nurjannah Nurjannah   +2 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Scalable and accurate rare variant meta-analysis with Meta-SAIGE. [PDF]

Nat Genet
Park E, Nam K, Jeong S, Keat K, Kim D, Bansal V, Zhou W, Lee S.   +7 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Fast and Memory-Efficient Dynamic Programming Approach for Large-Scale EHH-Based Selection Scans. [PDF]

Mol Biol Evol
Rahman A, Smith TQ, Szpiech ZA.
europepmc   +1 more source