Results 141 to 150 of about 107,800 (203)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Editorial: Bridging computation, biophysics, medicine, and engineering in neural circuits. [PDF]

Front Neural Circuits
Kamiya H, Yamamoto H, Soriano J, Sato S, Omori T.   +4 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Refining estimation techniques for the Two-Sided Power Distribution: A data-sensitive perspective. [PDF]

PLoS One
Güral Y.
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Exposure to per- and polyfluoroalkyl substances and adult cardiometabolic health: a Canadian Health Measures Survey mixture analysis. [PDF]

Environ Health
Hu JMY, Borghese MM, St-Amand A.
europepmc   +1 more source

Male infertility and risk of cardiometabolic conditions: a population-based cohort study. [PDF]

Hum Reprod
Marozzi J, Hanly M, Venetis C, O'Bryan MK, McLachlan R, Chambers GM.   +5 more
europepmc   +1 more source

A new automatic forecasting method based on explainable deep dendritic artificial neural network. [PDF]

Sci Rep
Bas E, Egrioglu E.
europepmc   +1 more source

StatLLM: A Dataset for Evaluating the Performance of Large Language Models in Statistical Analysis. [PDF]

Sci Data
Song X, Lee L, Xie K, Liu X, Deng X, Hong Y.   +5 more
europepmc   +1 more source

An efficient solution to Hidden Markov Models on trees with coupled branches. [PDF]

IEEE Trans Signal Process
Vafa F, Hormoz S.
europepmc   +1 more source