Results 241 to 250 of about 2,065,553 (347)

Correction: Understanding overfitting in random forest for probability estimation: a visualization and simulation study. [PDF]

Diagn Progn Res
Barreñada L, Dhiman P, Timmerman D, Boulesteix AL, Van Calster B.   +4 more
europepmc   +1 more source

Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design

Advanced Science, EarlyView.
In this study, a computational pipeline is developed to systematically evaluate the conformational stability, disulfide bond reduction state, and aggregation and degradation tendencies of an anticancer VHH‐Fc fusion antibody. Based on the mechanistic insights, antibody variants with enhanced stability and increased yield are successfully designed. This
Yuan Fang, Menghua Song, Tianning Pu, Xiaoqing Song, Kailu Xu, Pengcheng Shen, Ting Cao, Yiman Zhao, Simon Hsu, Dongmei Han, Qiang Huang   +10 more
wiley   +1 more source

Comparative analysis of heart disease prediction using logistic regression, SVM, KNN, and random forest with cross-validation for improved accuracy. [PDF]

Sci Rep
Rimal Y, Sharma N, Paudel S, Alsadoon A, Koirala MP, Gill S.   +5 more
europepmc   +1 more source

Reviewer #1 (Public Review): Lipid discovery enabled by sequence statistics and machine learning

Priya M. Christensen, Jonathan Martin, Aparna Uppuluri, Luke R. Joyce, Yahan Wei, Ziqiang Guan, Faruck Morcos, Kelli L. Palmer   +7 more
openalex   +1 more source

Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management

Advanced Science, EarlyView.
Electroactive platforms offer promising applications in cardiac arrhythmia. Based on their energy sources and mechanisms, electroactive platforms are categorized into i) direct electrical stimulation, ii) self‐powered electroactive systems, iii) physical stimuli‐mediated electroactive systems, and iv) conductive systems, and their applications in ...
Juwei Yang, Longfei Li, Yiran Hu, Zhou Li, Wei Hua   +4 more
wiley   +1 more source

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

Advanced Science, EarlyView.
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin, Shuzhen Liu, Mingshuo Zhan, Jian‐Dong Huang   +3 more
wiley   +1 more source

Machine learning analysis of factors contributing to hypotension after lumbosacral epidural anaesthesia in dogs undergoing abdominal surgery. [PDF]

Sci Rep
Parreño CM, Giles D, Corletto F.
europepmc   +1 more source

AlphaFold‐Guided Bespoke Gene Editing Enhances Field‐Grown Soybean Oil Contents

Advanced Science, EarlyView.
An AlphaFold‐guided method is developed to functionally optimize soybean sugar transporters and achieve bespoke gene editing of GmSWEET10a/b to improve oil content in an elite soybean cultivar in multi‐year, multi‐site field trials. The combination of AI‐guided protein design and gene editing may unlock a huge potential to improve the genetic trait de ...
Jie Wang, Li Zhang, Shoudong Wang, Xin Wang, Suning Li, Pingping Gong, Mengyan Bai, Arnav Paul, Nathan Tvedt, Hengrui Ren, Maoxiang Yang, Zhihui Zhang, Shaodong Zhou, Jiayi Sun, Xianjin Wu, Huaqin Kuang, Zhenghua Du, Yonghui Dong, Xiaolei Shi, Meina Li, Diwakar Shukla, Long Yan, Yuefeng Guan   +22 more
wiley   +1 more source

Machine learning-driven imaging data for early prediction of lung toxicity in breast cancer radiotherapy. [PDF]

Sci Rep
Ungvári T, Szabó D, Győrfi A, Dankovics Z, Kiss B, Olajos J, Tőkési K.   +6 more
europepmc   +1 more source

Interference Pattern Caused by Bilateral Bone Conduction Stimulation Impairs Sound Localization

Advanced Science, EarlyView.
This work explores how crosstalk‐induced wave interference affects bone conduction (BC) sound localization. Using a theoretical model, cadaveric vibrometry, and psychoacoustic tests, atypical BC lateralization patterns are revealed that contradict air conduction (AC) principles.
Liu‐Jie Ren, Yi Yu, Cheng Hua, You‐Zhou Xie, Wen‐Juan Yao, Jun‐Yi Liang, Chen‐Long Li, Tian‐Yu Zhang   +7 more
wiley   +1 more source