Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System
This study introduces a novel approach combining molecular dynamics simulations and neural network modeling to predict the Cas12a trans‐cleavage activity. By integrating sequence and molecular interaction features, prediction accuracy is enhanced, and identify key features affecting Cas12a trans‐cleavage activity.
Zhihao Yao+7 more
wiley +1 more source
A meta-analysis of the diagnostic test accuracy of artificial intelligence predicting emergency department dispositions. [PDF]
Kuo KM, Chang CS.
europepmc +1 more source
The presence of a micropapillary (MPP) component is critical for lung adenocarcinoma (LUAD) surgery, yet reliable blood biomarkers remain lacking. This study integrates proteomics for biomarker identification, a nanomixing‐enhanced surface‐enhanced Raman spectroscopy (SERS) platform for sensitive detection, and machine learning for accurate ...
Dechun Zhang+4 more
wiley +1 more source
Enhancing Sealing Performance Predictions: A Comprehensive Study of XGBoost and Polynomial Regression Models with Advanced Optimization Techniques. [PDF]
Zhou W, Xie Z.
europepmc +1 more source
Machine learning for early prediction of the infection in patients with urinary stone after treatment of holmium laser lithotripsy. [PDF]
Xia W+6 more
europepmc +1 more source
Machine learning identifies genes linked to neurological disorders induced by equine encephalitis viruses, traumatic brain injuries, and organophosphorus nerve agents. [PDF]
Yin L+9 more
europepmc +1 more source
A hybrid machine learning model with attention mechanism and multidimensional multivariate feature coding for essential gene prediction. [PDF]
Yan W+8 more
europepmc +1 more source