Results 81 to 90 of about 59,844 (197)

Highly Potent Fluorogenic Ligands for Triplex DNA: 5‐Substituted 2‐(Naphthalen‐2‐yl)‐4H‐Chromen‐4‐Ones

open access: yesChemistry – A European Journal, EarlyView.
5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran   +4 more
wiley   +1 more source

An observation‐driven state‐space model for claims size modelling

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract State‐space models are popular in econometrics. Recently, these models have gained some popularity in the actuarial literature. The best known state‐space models are of the Kalman‐filter type. These are called parameter‐driven because the observations do not impact the state‐space dynamics.
Jae Youn Ahn   +2 more
wiley   +1 more source

Hidden Markov graphical models with state‐dependent generalized hyperbolic distributions

open access: yesCanadian Journal of Statistics, EarlyView.
Abstract In this article, we develop a novel hidden Markov graphical model to investigate time‐varying interconnectedness between different financial markets. To identify conditional correlation structures under varying market conditions and accommodate shape features embedded in financial time series, we rely upon the generalized hyperbolic family of ...
Beatrice Foroni   +2 more
wiley   +1 more source

Real‐World Edoxaban Concentrations in Older Patients Receiving Reduced‐Dose Regimens

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Real‐world edoxaban concentrations in older patients receiving reduced‐dose regimens. Low trough concentrations (< 12 ng/mL) were associated with an increased risk of thromboembolism. Among patients meeting the ELDERCARE‐AF criteria, low drug levels were more frequent with the 15 mg regimen than with the 30 mg regimen.
Sung‐Chun Tang   +8 more
wiley   +1 more source

Rockburst prediction based on data preprocessing and hyperband‐RNN‐DNN

open access: yesDeep Underground Science and Engineering, EarlyView.
A data preprocessing workflow is proposed to address challenges in rockburst data analysis. Coupled algorithms preprocess the data set, and hyperband optimization is used to enhance RNN performance. Results show that preprocessing improves accuracy, while dense layers enhance model stability and prediction performance.
Yong Fan   +4 more
wiley   +1 more source

An optimizing microseismic method for rock burst early warning based on mining production process

open access: yesDeep Underground Science and Engineering, EarlyView.
A classification early warning method of rock burst based on hourly microseismic data is proposed, which can be combined with the on‐site production process to provide more timely warning. Abstract Microseismic (MS) events have been reported in nearly every coal mining country, which could well lead to rock burst in underground coal mines.
Zepeng Han   +6 more
wiley   +1 more source

From shadows to data: first robust population assessment of snow leopards in Pakistan

open access: yesEcography, EarlyView.
The snow leopard Panthera uncia is a flagship species of the greater Himalayan region and symbolizes the integrity of this ecological system. Within the greater Himalayas, Pakistan holds special significance as the north of the country represents a confluence of three major mountain ranges (Hindu Kush, Pamir–Karakoram, and Himalaya).
Muhammad Ali Nawaz   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy